AI Used to Assess Treatment Response for Brain Tumors

Researchers from Heidelberg University Hospital and the German Cancer Research Centre have developed a new method for the automated image analysis of brain tumors. In their recent publication, the authors show that machine learning methods carefully trained on standard MRI are more reliable and precise than established radiological methods in the treatment of brain tumors. Thus, they make a valuable contribution to the individualized treatment of tumors. In addition, the validated method is an important first step towards the automated high-throughput analysis of medical image data of brain tumors. One of the essential criteria for the precise assessment of the efficacy of a new therapy for brain tumors is the growth dynamic, which is determined by MRI. However, the manual measurement of tumor expansion in two planes in the contrast-enhanced MRI scans is prone to errors and leads to slightly different results. "This can have a negative effect on the assessment of therapy response and hence the reproducibility and precision of scientific statements based on imaging," Martin Bendszus, Medical Director of the Department of Neuroradiology at the University Hospital in Heidelberg, said in a release. In their current study, doctors and scientists from the University Hospital of Heidelberg and the German Cancer Research Center describe the huge potential of machine learning methods in radiological diagnostics. The team has developed neuronal networks in order to assess and...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news

Related Links:

Researchers from the University of Strathclyde have developed a blood test that could help to accelerate the diagnosis of brain cancer. The technology uses infrared light to produce a "bio-signature" of a blood sample and applies artificial intelligence to check for the signs of cancer. This research is being commercialized by ClinSpec Diagnostics Ltd, a company spun out from the university in February 2019. The work has now been published in the journal Nature Communications, and also involved clinicians at the Western General Hospital in Edinburgh, the University of Liverpool and the Walton NHS Foundation Trust...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Digital Health Source Type: news
Abstract13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1)...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Author Katie Smith, 33, from Stourbridge, West Midlands, won Lorraine's Top Tales prize in 2016. Appearing on the show today, she revealed she lives her life 'three months at a time' between scans.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
How can you have a moonshot trying to cure cancer and not mention people dying of cancer?I believed the narrative that is pushed on women, that if you check your breasts and if you catch it early, you’re fine.ide class="right-rail__container right-rail__container--ad"> Lianne Kraemer had been living with metastatic breast cancer for more than a year when I met her in December 2017 at the Henry B. González Convention Center in San Antonio. Throughout the week, more than 7,000 doctors, scientists and pharmaceutical-company representatives would descend on the city for the country’s most impor...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Breast Cancer health Source Type: news
ConclusionsThese findings provide evidence from molecular, cellular, and physiological levels that strongly suggest that CC12 is a promising small-molecule agent for human GBM.Legal entity responsible for the studyThe author.FundingHas not received any funding.DisclosureThe author has declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Conclusion The LoG-Glio registry has been successfully implemented. Applied selection criteria result in an appropriately balanced patient cohort. Short-term outcome data on epidemiology as well as the influence of current surgical techniques and adjuvant treatment on patient outcomes are expected. In the long run, the aim of the registry is to validate the new molecular-based WHO classification and the influence of the extent of resection on progression-free survival and OS. The registry provides an open platform for future research projects benefiting patients with LGG. Trial registration NCT02686229 Clinica...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
CONCLUSION: Our results suggest that our algorithm can non-invasively predict the 1p/19q status of presumed LGG with a performance that on average outperformed the oncological neurosurgeons . Evaluation on an independent dataset indicates that our algorithm is robust and generalizable. PMID: 31548344 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
ConclusionsThe combined drug treatment with glucose produced a large acute CEST MRI contrast indicating tumor acidification, which could be used to help localize brain cancer and monitor tumor response to chemotherapy.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
In this study, five non-small cell lung cancer cell lines with different levels of EGFR were used to investigate their ability to recognize EGFR expression through in vitro, ex vivo and in vivo experiments with [68Ga]Ga-NOTA-Affibody probes, and then to evaluate the value of positron emission tomography (PET) imaging in vivo diagnosis of EGFR-positive tumors. Methods: Purified Affibody analogues (Ac-Cys-ZEGFR:1907, bond to EGFR), synthesized by solid phase, and 1,4,7-three nitrogen heterocyclic nonane-1,4-7-three acetic acid (NOTA) produced conjugated compounds NOTA-ZEGFR:1907, which was labeled by [68Ga]Ga at 80℃ for 15...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research
Conclusions: NIRF imaging using Cy5.5-RKL is promising not only for diagnostic purposes but also for use in image-guided surgery for orthotopic glioblastoma or other superficial tumors. Key Words: Near-infrared fluorescence imaging, glioblastoma, RGD, NGR, anti-cancer peptide Suppl. Fig. 1: Confocal microscopy images of U87MG cells incubated with Cy5.5-RKL (50 nM of Cy5.5 labeled peptides in 500 μL of PBS) (magnification x60). For the blocking group, the U87MG cells were co-incubated with extra unlabeled peptide (50 μM). The results were scanned under confocal laser-scanning microscopy. Suppl. Fig. 2: In vivo fluores...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Multimodality and Nonradioactive Probes Posters Source Type: research
More News: Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Databases & Libraries | Germany Health | Hospitals | Learning | Medical Devices | Neurology | Neuroscience | PET Scan | Study | Universities & Medical Training