Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS

This study suggests that perturbations in histidine metabolism selectively target neural tumours that grow via a dedifferentiation process involving large cell size increases driven by Myc.

Source: EMBO Journal - March 31, 2019 Category: Molecular Biology Authors: Froldi, F., Pachnis, P., Szuperak, M., Costas, O., Fernando, T., Gould, A. P., Cheng, L. Y. Tags: Cancer, Neuroscience Articles Source Type: research