PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma.

CONCLUSIONS: We propose that PGK1 mediates DNA repair and methylation through the HSP90/ERK pathway, and eventually enhances the chemoresistance to cisplatin. The results provide new insights on functions of PGK1 and HSP90, which might make them as promising targets for endometrial cancer chemotherapy. PMID: 30925862 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30925862?dopt=Abstract

Source: Molecular Medicine - March 28, 2019 Category: Molecular Biology Authors: Zhou JW, Tang JJ, Sun W, Wang H Tags: Mol Med Source Type: research