Primary gastrointestinal aspergillosis: a case report and literature review.

Primary gastrointestinal aspergillosis: a case report and literature review. Infez Med. 2019 Mar 01;27(1):85-92 Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibiotics and caspofungin treatment, and intestinal perforation occurred on the nineteenth day of the febrile neutropenic episode. Pathological examination of the resected jejunum and ileum revealed mould hyphae compatible with aspergillus. The patient died due to massive gastrointestinal bleeding on the fifth post-operative day. Although a rare condition, primary gastrointestinal aspergillosis should be kept in mind while treating neutropenic patients with gastrointestinal symptoms. PMID: 30882385 [PubMed - in process]
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research

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Conclusion: Treatment of systemic loxoscelism involves aggressive supportive care including appropriate wound management, blood transfusions, intravenous fluid replacement, and appropriate antibiotic coverage. It is unclear at this time if glucocorticoids or IVIg has any beneficial impact on the treatment of severe loxoscelism. PMID: 31015839 [PubMed]
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
LPS‑induced upregulation of the TLR4 signaling pathway inhibits osteogenic differentiation of human periodontal ligament stem cells under inflammatory conditions. Int J Mol Med. 2019 Jun;43(6):2341-2351 Authors: Yu B, Li Q, Zhou M Abstract Toll‑like receptor 4 (TLR4) is a transmembrane receptor responsible for the activation of a number of signal transduction pathways. Despite its involvement in inflammatory processes, the regulation of TLR4 signaling in human periodontal ligament stem cells (hPDLSCs) under inflammatory conditions remains to be fully elucidated. The present study aimed to clarify ...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
CONCLUSIONS: It is known that CE can miss clinically relevant and serious lesions. Our results suggest that patients with an initially negative or inconclusive CE frequently have a cause of SB bleeding detected on repeat CE. The DY of repeat CE is highest in those with bleeding on their initial CE (83.3%) and lower in those with initially normal examinations (45.8%) or when an alternative cause, such as angioectasia is seen (14.2%). PMID: 31017489 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 24 April 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Suet Lee Shirley Ding, Avin Ee-Hwan Koh, Suresh Kumar, Mohammed Safwan Ali Khan, Badr Alzahrani, Pooi Ling MokAbstractDysfunctional or death of retinal photoreceptors is an irreversible phenomenon that is closely associated with a broad range of retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration (AMD), resulting in successive loss of visual function and blindness. In search for viable treatment for retinal degenerative diseases, mesenchymal stem cells (MSCs) h...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Conclusion: Preoperative levels of serum leptin were higher in C-section patients with labor pain than in those without labor pain, and increased serum leptin levels were associated with decreased preoperative pain t hreshold and increased postoperative analgesic consumption in our study population. Postoperative analgesic requirements may vary among patients, and their requirements might be predicted using preoperative indicators. Serum levels of leptin might be one such indicator and this warrants further stud ies with larger sample sizes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
RATIONALE: Damage control is a staged surgical approach to manage polytraumatized patients. The damage control approach comprises three steps. First, bleeding is controlled and fractures are stabilized temporarily; second, vital parameters are stabilized a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Critical care trainee here (in australasia critical care runs both medical and surgical ICUs). I've been hearing a lot recently about the approach of permissive hypotensive, that is permitting SBPs of 60-70 in actively bleeding patients to stop "the clot from popping" and prevent dilutional coagulopathy while waiting for damage control. I've read the evidence around it and I understand it exists but is underpowered. Wondering what everybodys experience is with this strategy and how you all... Permissive hypotension
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Surgery and Surgical Subspecialties Source Type: forums
From enuresis to incontinence, urologic symptoms can impact individuals of all genders throughout the lifespan. Urologic conditions may cause physical pain or psychological discomfort that can have tremendous negative impact on an individual ’s well-being. Urologic symptoms, such as dysuria, hematuria, erectile dysfunction, and bladder pain, are common and yet are all too often underreported to primary care physicians. Some patients are embarrassed to discuss symptoms, while others may mistakenly believe that there is no treatment ava ilable that can be helpful.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Tags: Preface Source Type: research
Incidence of nephrolithiasis has increased dramatically over the past 30  years, likely due to environmental changes such as dietary habits. Nephrolithiasis presents as acute flank or abdominal pain with nausea and vomiting. Hematuria is present in 90% of cases, but its absence does not rule out nephrolithiasis. Most cases can be managed expectantly as an outpatient wit h hydration, analgesia, and possibly medications to aide in passage. A metabolic evaluation may be indicated after a second episode of nephrolithiasis in adults or after a first episode in children or those with a family history of nephrolithiasis.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Source Type: research
Publication date: Available online 25 April 2019Source: Brain, Behavior, and ImmunityAuthor(s): Zoe Hore, Franziska DenkAbstractIt is widely accepted that communication between the nervous and immune systems is involved in the development of chronic pain. At each level of the nervous system, immune cells have been reported to accompany and frequently mediate dysfunction of nociceptive circuitry; however the exact mechanisms are not fully understood. One way to speed up progress in this area is to increase interdisciplinary cross-talk. This review sets out to summarize what pain research has already learnt, or indeed might ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
More News: Aspergillosis | Aspergillus | Bleeding | Cancidas | Caspofungin | Gastroenterology | Infectious Diseases | Lung Transplant | Lymphoma | Non-Hodgkin's Lymphoma | Pain | Stem Cell Therapy | Stem Cells | Transplants