Mitochondrial DNA Mismatches in Thoracic Transplantation: Potential Triggers of Allograft Immunogenicity

Organ transplant (Tx) recipients of non-European ancestry experience higher rejection rates. Stem cell research shows that single nucleotide variant mismatches (SNVMs) in mitochondria DNA (mtDNA) of the donor and host cells trigger alloimmune responses. However, no prior studies have addressed mtDNA SNVMs in organ transplantation. We hypothesized that SNVMs between donor-recipient (D-R) mtDNA sequences contribute to allograft immunogenicity. Our purpose was to conduct a proof-of-concept study examining the relationship between mtDNA SNVMs and immunogenicity in human thoracic Tx recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 156 Source Type: research