Fetal stem cell transplantation and gene therapy

Publication date: Available online 5 March 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Rachel Sagar, Cecilia Götherström, Anna L. David, Magnus WestgrenAbstractThen present chapter summarize our current knowledge on fetal stem cell and gene therapy. It focus on these therapeutic alternatives in regard to past experience and ongoing and planned studies in humans. Several methodological challenges are discussed that may have wide implications on how these methods could be introduced in clinical practice. Although, still promising the methods are afflicted with very special requirements not least in regard to safety and ethical questions. Furthermore, careful monitoring and extended follow-up of the child and his/hers mother who receive prenatal stem cell or gene treatments are of outmost importance. Taken these prerequisites into consideration it is natural that this type of experimental fetal therapies require collaboration between different disciplinaries, and institutions within medicine.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research