Systematic Review of Acceptability, Cardiovascular, Neurological, Bone Health, and HRT Outcomes following Risk Reducing Surgery in BRCA carriers
We present a comprehensive review of acceptability, selected health outcomes above and HRT safety following risk reducing surgery. (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - February 5, 2020 Category: OBGYN Source Type: research

Endometrial cancer prevention in high-risk women
Publication date: Available online 20 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Kelechi Njoku, Joanna Abiola, Johanna Russell, Emma J. CrosbieAbstractEndometrial cancer (EC) is the most common gynaecological malignancy, and its incidence is rising alongside the growing prevalence of obesity. Effective risk-reducing interventions hijacking the key mechanisms driving endometrial carcinogenesis may affect EC diagnoses if aimed at those at greatest risk. An understanding of the key risk factors and their role in tumourigenesis is critical in developing such prevention str...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 28, 2020 Category: OBGYN Source Type: research

Rheumatic diseases and maternal-fetal medicine
Publication date: Available online 17 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Wendy Marder, Timothy R.B. Johnson (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 25, 2020 Category: OBGYN Source Type: research

Self-care provision of contraception: Evidence and insights from contraceptive injectable self-administration
Publication date: Available online 23 January 2020Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Martha Brady, Jennifer Kidwell Drake, Allen Namagembe, Jane CoverAbstractAs new reproductive health products become available, women increasingly want to take a participatory role in their health. New developments and formulations of contraceptive products provide an opportunity to support this evolving trend toward self-care. Self-care, as defined by the World Health Organization (WHO), highlights the ability of individuals to promote health, prevent disease, and manage their own health wi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 23, 2020 Category: OBGYN Source Type: research

Abortion: Global perspectives and country experiences - Multiple choice questions vol. 62
Publication date: January 2020Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 62Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 21, 2020 Category: OBGYN Source Type: research

Index
Publication date: January 2020Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 62Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 21, 2020 Category: OBGYN Source Type: research

Postpartum haemorrhage – Multiple choice answers vol. 61
Publication date: January 2020Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 62Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 21, 2020 Category: OBGYN Source Type: research

Editorial Board
Publication date: January 2020Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 62Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 21, 2020 Category: OBGYN Source Type: research

Genetic Testing for Epithelial Ovarian Cancer
Publication date: Available online 16 January 2020Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Noa Amin, Narda Chaabouni, Angela GeorgeAbstractAs the treatment of epithelial ovarian cancer moves further into personalised medicine, the importance of determining the presence or absence of inherited mutations in cancer susceptibility genes has grown. It is now becoming routine to test for germline mutations in the BRCA1 and BRCA2 genes, which are responsible for a significant proportion of hereditary epithelial ovarian cancer and are established predictive biomarkers of potential benefi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 18, 2020 Category: OBGYN Source Type: research

Rheumatologic diseases and maternal medicine
Publication date: Available online 17 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Wendy Marder, Timothy R.B. Johnson (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 10, 2020 Category: OBGYN Source Type: research

Modern methods to induce abortion: safety, efficacy and choice
Publication date: Available online 9 January 2020Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Nathalie Kapp, Patricia A. LohrAbstractAbortion care is a fundamental part of women’s reproductive health care. Surgical and medical abortion methods are safe and effective throughout the gestational age range wherein abortions are performed. Although risks increase with the gestational age of the pregnancy being terminated, rates of complications remain low and comparable between surgical and medical techniques. A high-quality abortion service should offer women a choice between abort...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 10, 2020 Category: OBGYN Source Type: research

Current and future approaches to screening for endometrial cancer
Publication date: Available online 2 January 2020Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): A. Gentry-Maharaj, C. KarpinskyjAbstractDue largely to the rise in obesity and prolonged life expectancy, endometrial cancer rates have increased by 56% since the early 90s. Women at high risk (Lynch Syndrome) have a 12-47% lifetime risk of developing endometrial cancer and professional societies recommend annual surveillance using transvaginal ultrasound (TVS) and endometrial biopsy (outpatients hysteroscopy) from age 30-35 with hysterectomy from age 40. In women at low risk, screening is n...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - January 3, 2020 Category: OBGYN Source Type: research

Reviving permanent contraception: New medical procedures or new service delivery modalities?
Publication date: Available online 20 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Carmela Cordero-FrancoAbstractDespite the prevalent increase of permanent contraception there are still 222 million women with unmet needs for contraception; a large proportion of these women could opt for permanent contraception. New approaches to permanent contraception are in development; in the meantime services need to be accessible, affordable, safe, and convenient to allow women, men and couples to realize their reproductive intentions. Among the available approaches we recommend mi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 22, 2019 Category: OBGYN Source Type: research

Fertility Awareness-Based Methods of Family Planning
Publication date: Available online 20 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Rebecca Simmons, Victoria JenningsAbstractFertility awareness-based methods of family planning (FABMs) involve monitoring various signs and symptoms of fertility during the menstrual cycle to identify the “fertile window,” or the days of the cycle when unprotected intercourse is most likely to result in pregnancy. Signs and symptoms include menstrual cycle length, basal body temperature, urinary hormone measurements, and/or cervical fluid and may be used alone or in combination...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 22, 2019 Category: OBGYN Source Type: research

Long-acting reversible contraceptive (LARCs) methods
Publication date: Available online 20 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Luis Bahamondes, Arlete Fernandes, Ilza Monteiro, M. Valeria BahamondesAbstractUnplanned pregnancy (UP) is a public health problem which affects millions of women worldwide. Providing long-acting reversible contraceptive (LARC) methods is an excellent strategy to avoid or at least reduce UP, because the effectiveness of these methods is higher than for other methods, and is indeed comparable to that of permanent contraception. Since the initial introduction of the inert plastic intrauterin...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 22, 2019 Category: OBGYN Source Type: research

Endometrial Cancer Prevention in High Risk Women
Publication date: Available online 20 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Kelechi Njoku, Joanna Abiola, Johanna Russell, Emma J. CrosbieAbstractEndometrial cancer is the most common gynaecological malignancy and its incidence is rising alongside the growing prevalence of obesity. Effective risk reducing interventions hijacking the key mechanisms driving endometrial carcinogenesis may reduce endometrial cancer diagnoses if aimed at those at greatest risk. An understanding of the key risk factors and their role in tumourigenesis is critical in developing such prev...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 21, 2019 Category: OBGYN Source Type: research

Preface: Volume 65
Publication date: Available online 17 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Wendy Marder, Timothy R.B. Johnson (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 18, 2019 Category: OBGYN Source Type: research

Male and female condoms: Their key role in pregnancy and STI/HIV prevention
Publication date: Available online 14 December 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Mags Beksinska, Rachel Wong, Jenni SmitAbstractMale and female condoms are the only available multi-purpose technology (MPT) that can prevent unintended pregnancy and sexually transmitted infections including HIV. If used correctly and consistently, condoms can provide levels of pregnancy protection similar to many hormonal methods. Condoms remain one of the most common methods used at first sexual intercourse and are relied on as a current use of contraception by adolescents in many regio...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 14, 2019 Category: OBGYN Source Type: research

Breast cancer prevention in high-risk women
Publication date: Available online 21 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Mangesh A. Thorat, Rajeshkumar BalasubramanianAbstractWomen at high risk of developing breast cancer are a heterogeneous group of women including those with and without high-risk germline mutation/s. Prevention in these women requires a personalised and multidisciplinary approach. Preventive therapy with selective oestrogen receptor modulators (SERMs) like tamoxifen and aromatase inhibitors (AIs) substantially reduces breast cancer risk well beyond the active treatment period. The importan...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 12, 2019 Category: OBGYN Source Type: research

Risk-based breast cancer screening strategies in women
Publication date: Available online 18 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Elaine F. Harkness, Susan M. Astley, D.Gareth EvansAbstractThe incidence of breast cancer continues to increase worldwide. Population-based screening is available in many countries but may not be the most efficient use of resources, thus interest in risk-based/stratified screening has grown significantly in recent years. An important part of risk-based screening is the incorporation of mammographic density (MD) and single nucleotide polymorphisms (SNPs) into risk prediction models to be co...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - December 4, 2019 Category: OBGYN Source Type: research

Postpartum haemorrhage - multiple choice questions vol. 61
Publication date: November 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 61Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 26, 2019 Category: OBGYN Source Type: research

Immunology in obstetrics and gynaecology - Multiple choice answers vol. 60
Publication date: November 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 61Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 26, 2019 Category: OBGYN Source Type: research

Index
Publication date: November 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 61Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 26, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: November 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 61Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 26, 2019 Category: OBGYN Source Type: research

Ovarian protection with gonadotropin-releasing hormone agonists during cyclophosphamide therapy in systemic lupus erythematosus
Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Ruba Kado, W. Joseph McCuneAbstractAdministration of cyclophosphamide (CYC), an alkylating agent used to treat malignancies and severe rheumatic diseases, creates a risk of ovarian insufficiency that is related to the intensity and duration of therapy and the age of the patient. To preserve reproductive capacity in the appropriate clinical setting, oocyte, embryo, and/or ovarian tissue cryopreservation are recommended. Medical protection with depot gonadotropin-releasing hormone agonists (...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 26, 2019 Category: OBGYN Source Type: research

Long-term outcome of children born from mothers with autoimmune diseases
Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in family planning. Pregnancies in these patients may carry several complications but nowadays the continued amelioration in treatment and management has greatly improved the pregnancy outcome. The main concern of these women obviously is the short- and long-term outcome of their children. A child born from a ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 25, 2019 Category: OBGYN Source Type: research

Breast cancer prevention in high risk women
Publication date: Available online 21 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Mangesh A. Thorat, Rajeshkumar BalasubramanianAbstractWomen at a high-risk of developing breast cancer are a heterogenous group of women including those with and without high-risk germline mutation/s. Prevention in these women requires a personalised and multidisciplinary approach. Preventive therapy with Selective oestrogen receptor modulators (SERMs) like tamoxifen and aromatase inhibitors (AIs) substantially reduces breast cancer risk well beyond active treatment period. The importance ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 22, 2019 Category: OBGYN Source Type: research

Chapter 9: Risk-based breast cancer screening strategies in women
Publication date: Available online 18 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Elaine F. Harkness, Susan M. Astley, D Gareth EvansAbstractThe incidence of breast cancer continues to increase worldwide. Population-based screening is available in many countries but may not be the most efficient use of resources, thus interest in risk-based/stratified screening has grown significantly in recent years. An important part of risk-based screening is the incorporation of mammographic density and single nucleotide polymorphisms (SNPs) into risk prediction models to be combine...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2019 Category: OBGYN Source Type: research

Medications in pregnancy and breastfeeding
Publication date: Available online 15 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Sofia Tosounidou, Caroline GordonAbstractAdvances in therapeutics, including a wider use of biologics and targeted synthetic disease modifying drugs (DMARDs) have substantially improved the management of rheumatic diseases, resulting in more women with severe disease considering pregnancy. Every clinical rheumatologist has encountered a woman who wishes to have a pregnancy - or who presents already pregnant - and who values the importance of reliable information on rheumatic diseases and s...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 16, 2019 Category: OBGYN Source Type: research

Ovarian protection with gonadotropin releasing hormone agonists during cyclophosphamide therapy in systemic lupus erythematosus
Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Ruba Kado, W. Joseph McCuneAbstractAdministration of cyclophosphamide (CYC), an alkylating agent used to treat malignancies and severe rheumatic diseases, creates a risk of ovarian insufficiency that is related to the intensity and duration of therapy and the age of the patient. To preserve reproductive capacity in the appropriate clinical setting, oocyte, embryo, and/or ovarian tissue cryopreservation are recommended. Medical protection with depot-gonadotropin releasing hormone agonists (...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 14, 2019 Category: OBGYN Source Type: research

Pregnancy And Autoimmune Diseases
Publication date: Available online 14 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Emily C. SomersAbstractAutoimmune diseases (AID) are more prevalent in women than men, and pregnancy-related factors such as hormonal modulation and fetal microchimerism may influence future risk of maternal AID. For women with AID, optimizing reproductive health requires a continuum of multidisciplinary care that initiates well before the desire for pregnancy is articulated. Family planning is essential so that pregnancy can be timed when disease is stable and to allow for appropriate med...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 14, 2019 Category: OBGYN Source Type: research

Ong term outcome of children born from mothers with autoimmune diseases
Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in the family planning. Pregnancies in these patients may carry several complications but nowadays the continue amelioration in treatment and management have greatly improved the pregnancy outcome. The main concern of these women obviously are the short- and long-term outcome of their children. A child born fr...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 13, 2019 Category: OBGYN Source Type: research

Immunology in obstetrics and gynaecology - Multiple choice questions Vol. 60
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Advances in reproductive surgery – Multiple choice answers Vol. 59
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Index
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Contraception and preconception counseling in women with autoimmune disease
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Lisa R. SammaritanoAbstractAppropriate contraception and preconception counseling are critical for women of reproductive age with systemic autoimmune diseases (AIDs) because clinical diagnosis, rheumatology medications, and disease activity may impact the safety or efficacy of certain contraceptives as well as the risk of adverse pregnancy outcomes. The presence of antiphospholipid (aPL) antibodies (anticardiolipin, anti-β2 glycoprotein I, and lupus anticoagulant) is the most important ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 26, 2019 Category: OBGYN Source Type: research

Assisted Reproductive Technologies For Women With Rheumatic Aid
Publication date: Available online 23 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Michael D. LockshinAbstractART procedures are safe for women with rheumatic autoimmune diseases (rAID) when illness is inactive. Medications incompatible with pregnancy should change to alternative, pregnancy-compatible medications months before planned ART procedures to allow time to verify the substitute medication’s efficacy and tolerability. Medications compatible with pregnancy should continue, as should anticoagulation (warfarin changing to low molecular weight heparin) before p...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 24, 2019 Category: OBGYN Source Type: research

Antiphospholipid syndrome: Diagnosis and management in the obstetric patient
Publication date: Available online 17 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Erol Arslan, D. Ware BranchAbstractAntiphospholipid syndrome (APS) is a rare condition characterized clinically by thrombotic events or pregnancy complications and confirmed by one or more repeatedly positive anti-phospholipid (aPL) antibodies on two or more occasions at least 12 weeks apart. Several factors are thought to have roles in pathogenesis of adverse obstetric events related to APS, including platelet and endothelial cell activation, complement activation, and ultimate activation ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 18, 2019 Category: OBGYN Source Type: research

Pregnancy in Myositis and Scleroderma
Publication date: Available online 18 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Sirajum Munira, Lisa Christopher-StineAbstractMyositis and scleroderma are both rare autoimmune diseases with female predominance and often occur before and during reproductive years. The rarity of diseases explains the low frequency of concurrent disease and pregnancy. Like other autoimmune diseases, myositis and scleroderma may be more active during pregnancy as well. To date, many patients with myositis and scleroderma can have favorable pregnancy outcomes with careful management. This c...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 18, 2019 Category: OBGYN Source Type: research

Pregnancy and rheumatoid arthritis
Publication date: Available online 9 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Emily Adele LittlejohnAbstractRheumatoid arthritis commonly affects women of childbearing age. Fertility, family planning, control of disease activity and birth outcomes are all important issues to be discussed at preconception counseling. New data has offered insight on trends of fertility, disease control during pregnancy, and birth outcomes. This chapter provides an updated overview on expected disease course and management issues at each juncture with a particular focus on maintenance of...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 11, 2019 Category: OBGYN Source Type: research

Paternal safety of anti-rheumatic medications
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Bonnie L. BermasAbstractResearch into the safety of medications used to treat rheumatic diseases in men wishing to conceive is lacking. When evaluating medication safety for potential fathers, there are two major reproductive issues to consider first whether a drug induces infertility and second whether a drug can cause adverse pregnancy outcomes. Cyclopshophamide is the only medication used in rheumatic disease management that causes irreversible infertility. All men prescribed cyclophospha...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Contraception and Pre-conception Counseling in Women with Autoimmune Disease
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Lisa R. SammaritanoAbstractAppropriate contraception and preconception counseling are critical for women of reproductive age with systemic autoimmune diseases since clinical diagnosis, rheumatology medications, and disease activity may impact the safety or efficacy of certain contraceptives as well as the risk of adverse pregnancy outcomes. The presence of antiphospholipid antibodies (anticardiolipin, anti-β2 Glycoprotein I and lupus anticoagulant) is the most important determinant of c...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Pregnancy and Systemic Lupus Erythematosus
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Michelle PetriAbstractAs SLE onset is often in young adulthood, pregnancy is common and is usually successful. Pregnancy, though, is considered high-risk due to a combination of maternal (lupus flare, diabetes, pre-eclampsia) and fetal (miscarriage, intrauterine fetal demise, preterm birth, intrauterine growth restriction, congenital heart block) risks.Pregnancy should be planned for a time of good control of SLE (on allowable medications). The antimalarial hydroxychloroquine should be conti...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Autoimmune-Mediated Congenital Heart Block
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Benjamin Wainwright, Rohit Bhan, Catherine Trad, Rebecca Cohen, Amit Saxena, Jill Buyon, Peter IzmirlyAbstractAutoimmune-mediated congenital heart block (CHB) is a severe manifestation of neonatal lupus in which conduction tissues of the fetal heart are damaged. This occurs due to passive transference of maternal Ro (SSA) and La (SSB) autoantibodies, and subsequent inflammation and fibrosis of the atrioventricular (AV) node. Notably, the disease manifests after the fetal heart has structural...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Advances in reproductive surgery – Multiple choice questions Vol. 59
Publication date: August 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 59Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - September 19, 2019 Category: OBGYN Source Type: research

Fetal therapy – Multiple choice answers Vol. 58
Publication date: August 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 59Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - September 19, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: August 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 59Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - September 19, 2019 Category: OBGYN Source Type: research

Index
Publication date: August 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 59Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - September 19, 2019 Category: OBGYN Source Type: research

Self-managed abortion: a systematic scoping review
Publication date: Available online 22 August 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Heidi Moseson, Steph Herold, Sofia Filippa, Jill Barr-Walker, Sarah E. Baum, Caitlin GerdtsAbstractSelf-managed abortion, when a person performs their own abortion without clinical supervision, is a model of abortion care used across a range of settings. To provide a comprehensive synthesis of the available literature on self-managed abortion, we conducted a systematic search for peer-reviewed research in April 2019 in PubMed, Embase, Web of Science, Popline, PsycINFO, Google Scholar, Scielo...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - August 23, 2019 Category: OBGYN Source Type: research