Gambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer

In conclusion, GA micelles which showed high-efficiency anti-tumor effect in vitro and in vivo may serve as a candidate for pancreatic cancer therapyGraphical abstractMonomethyl poly(ethylene glycol)-poly(ε-caprolactone)-poly(trimethylene carbonate) (MPEG-P(CL-ran-TMC)) copolymer was synthesized, which could encapsulate GA by a single-step solid dispersion and form nano-sized micelles. The MPEG-P(CL-ran-TMC) based nano-formulation of GA could improve the anti-tumor effect in vivo, which may serve as a candidate for pancreatic cancer therapy.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research