Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer [Physiology]

SMAD2 and SMAD3 are downstream proteins in the transforming growth factor-β (TGF β) signaling pathway that translocate signals from the cell membrane to the nucleus, bind DNA, and control the expression of target genes. While SMAD2/3 have important roles in the ovary, we do not fully understand the roles of...

Source: Proceedings of the National Academy of Sciences - February 26, 2019 Category: Science Authors: Maya Kriseman, Diana Monsivais, Julio Agno, Ramya P. Masand, Chad J. Creighton, Martin M. Matzuk Tags: PNAS Plus Source Type: research