Cancers, Vol. 11, Pages 264: Deciphering the Mechanism of Action Involved in Enhanced Suicide Gene Colon Cancer Cell Killer Effect Mediated by Gef and Apoptin

In conclusion, in this manuscript we demonstrate for the first time that the extrinsic pathway of apoptosis and pore formation is also involved in the cell death caused by the co-expression of the gef and apoptin genes. Our results suggest that co-expression of gef and apoptin genes induces an increase in post-apoptotic necrotic cell death and could be a valuable tool in the design of new antitumor strategies focused on the enhancement of the immune response against cancer cell death.

Source: Cancers - February 23, 2019 Category: Cancer & Oncology Authors: Blanca C áceres Alberto Ramirez Esmeralda Carrillo Gema Jimenez Carmen Gri ñán-Lisón Elena L ópez-Ruiz Yaiza Jim énez-Martínez Juan A. Marchal Houria Boulaiz Tags: Article Source Type: research