An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-{kappa}B and MAPK signaling via Toll-like receptor 4 [Immunology]

This study has identified the TPG-1 proteoglycan as an antitumor agent and provided insights into TPG-1's molecular mechanism, suggesting a potential utility for applying this agent in cancer therapy.

Source: Journal of Biological Chemistry - February 22, 2019 Category: Chemistry Authors: Ailin Yang, Haitao Fan, Yanan Zhao, Xiaonan Chen, Zhixiang Zhu, Xiaojun Zha, Yunfang Zhao, Xingyun Chai, Jun Li, Pengfei Tu, Zhongdong Hu Tags: Cell Biology Source Type: research