Iron-oxide nanoparticles target intracellular HSP90 to induce tumor radio-sensitization

ConclusionThis study reveals the key role of HSP90 in the mechanism of tumor radio-sensitization by MN-OA.General significancePresent work provides a deeper understanding about the mechanism of MN-OA-induced tumor radiosensitization, highlighting the role of HSP90 protein. In addition to diagnostic and magnetic hyperthermia abilities, present remarkable radiosensitizing activity of MN-OA would further excite the clinicians to test its anti-cancer potential.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research