(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease

The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle region peptide (HRP), on chronic kidney disease (CKD)-associated heart failure.

Source: Journal of Cardiac Failure - February 12, 2019 Category: Cardiology Authors: Akihiro Yoshida, Hiromitsu Kanamori, Genki Naruse, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Atsushi Mikami, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi Tags: Basic Science and Experimental Studies Source Type: research