Mouse model of anti-NMDA receptor post-herpes simplex encephalitis.

Conclusions: Mice inoculated intranasally with HSV-1 developed serum NMDAR antibodies. These antibodies were associated with reduced hippocampal NMDARs, as has been shown in previous models where antibodies from patients with anti-NMDAR encephalitis were infused into mice, paving the way for future studies into the pathophysiology of autoimmune encephalitides.
PMID: 30697582 [PubMed]

Source: Herpes - January 31, 2019 Category: Infectious Diseases Authors: Linnoila J, Pulli B, Armangué T, Planagumà J, Narsimhan R, Schob S, Zeller MWG, Dalmau J, Chen J Tags: Neurol Neuroimmunol Neuroinflamm Source Type: research