Molecules, Vol. 24, Pages 336: Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs —A Promising Approach to Fight Cancer Drug Resistance
Molecules, Vol. 24, Pages 336: Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs—A Promising Approach to Fight Cancer Drug Resistance
Molecules doi: 10.3390/molecules24020336
Authors:
Gabriella Spengler
Márió Gajdács
Małgorzata Anna Marć
Enrique Domínguez-Álvarez
Carmen Sanmartín
Malignant diseases present a serious public health burden and their treatment with traditional chemotherapy cannot be considered an all-round solution, due to toxic side effects. Selenium compounds (Se-compounds) have received substantial attention in medicinal chemistry, especially in experimental chemotherapy, both as cytotoxic agents and adjuvants in chemotherapy. A checkerboard microplate method was applied to study the drug interactions of Se-compounds and clinically relevant chemotherapeutic drugs against the multidrug-resistant (MDR) subtype of mouse t-lymphoma cells overexpressing the ABCB1 transporter. Se-compounds showed synergistic interactions with chemotherapeutic agents targeting the topoisomerase enzymes or the microtubule apparatus. The ketone-containing selenoesters showed synergism at lower concentrations (1.25 µM). Most of the tested compounds interacted antagonistically with alkylating agents and verapamil. A thiophene-containing Se-compound showed synergism with all tested drugs, except cisplatin. While the exact mechanism of drug interactions is yet unknown, the potency of the selenocompounds as efflux pump inhibitors or th...
Source: Molecules - Category: Chemistry Authors: Gabriella Spengler M árió Gajdács Ma łgorzata Anna Marć Enrique Dom ínguez-Álvarez Carmen Sanmart ín Tags: Communication Source Type: research
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