Intraperitoneal transplantation of bioengineered humanized liver grafts supports failing liver in acute condition

Publication date: May 2019Source: Materials Science and Engineering: C, Volume 98Author(s): Sandeep Kumar Vishwakarma, Avinash Bardia, Chandrakala Lakkireddy, Nagarapu Raju, Syed Ameer Basha Paspala, Md. Aejaz Habeeb, Aleem Ahmed KhanAbstractAcute liver failure (ALF) is one of the most devastating fatal conditions which have posed crucial challenges to the clinicians and researchers for identifying permanent cure. Currently liver transplantation has been considered as the only managerial option. However it's wider applicability has been limited owing to non-availability of quality donor organs, cost-intensiveness, surgical hitches, life-long use of immunosuppressive drugs and long-term complications. Since last decades, several liver support systems have been developed for the management of failing liver in acute condition. However, the major limitation has been the lack of natural biological support and long-term survival of the grafts post-transplantation. Repopulation of decellularized xenogeneic organs is one of the emerging technologies for development of humanized neo-organs for demanding regenerative application. However, the earlier reported studies do not fulfil the insistence to provide immunologically tolerable humanized liver grafts for clinical applications. Here we demonstrate an efficient approach to generate transplantable humanized liver grafts which provides long-term support to the failing liver in Acute Liver Failure (ALF) animal models. These bioengineere...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research