The impact of GPIb α on platelet-targeted FVIII gene therapy in hemophilia A mice with pre-existing anti-FVIII immunity.

CONCLUSION: GPIbα does not significantly impact platelet gene therapy of HA with inhibitors. 2bF8 gene therapy restores hemostasis and promotes immune tolerance in HA mice with pre-existing immunity. This article is protected by copyright. All rights reserved. PMID: 30609275 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30609275?dopt=Abstract

Source: Thrombosis and Haemostasis - January 4, 2019 Category: Hematology Authors: Chen J, Schroeder JA, Luo X, Montgomery RR, Shi Q Tags: J Thromb Haemost Source Type: research