Pathological changes in the COPD lung mesenchyme – Novel lessons learned from in vitro and in vivo studies

Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): Oluwaseun Ojo , Anna L. Lagan , Vijayanand Rajendran , Anita Spanjer , Ling Chen , Sukhwinder Singh Sohal , Irene Heijink , Robin Jones , Harm Maarsingh , Tillie L. Hackett Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death worldwide and, in contrast to the trend for cardiovascular diseases, mortality rates still continue to climb. This increase is in part due to an aging population, being expanded by the “Baby boomer” generation who grew up when smoking rates were at their peak and by people in developing countries living longer. Sadly, there has been a disheartening lack of new therapeutic approaches to counteract the progressive decline in lung function associated with the disease that leads to disability and death. COPD is characterized by irreversible chronic airflow limitation that is caused by emphysematous destruction of lung elastic tissue and/or obstruction in the small airways due to occlusion of their lumen by inflammatory mucus exudates, narrowing and obliteration. These lesions are mainly produced by the response of the tissue to the repetitive inhalational injury inflicted by noxious gases, including cigarette smoke, which involves interaction between infiltrating inflammatory immune cells, resident cells (e.g. epithelial cells and fibroblasts) and the extra cellular matrix. This interacti...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research