Major international project aims to identify causes of dementia

(Center for Genomic Regulation) European scientists have launched a research program, which aims to identify common causes of dementia in Alzheimer's Disease, Parkinson's Disease and Down Syndrome. The project brings together basic and clinical expertise of internationally recognized groups with complementary core competencies from clinical trials to neurobiology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Martin Sjøgård, Xavier De Tiège, Alison Mary, Philippe Peigneux, Serge Goldman, Guy Nagels, Jeroen van Schependom, Andrew J. Quinn, Mark Woolrich, Vincent WensAbstractThe default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. Non-invasive elect...
Source: NeuroImage - Category: Neuroscience Source Type: research
INTRODUCTION: Social networks play a role in slowing the development of dementia. However, there is a need for further investigation of the effects of improving social networks on health-related quality of life and cognitive performance. Targeted community...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Condition:   Dementia With Lewy Bodies Interventions:   Drug: Placebo oral capsule;   Drug: 96 mg of K0706;   Drug: 192 mg K0706 Sponsors:   Georgetown University;   Sun Pharma Advanced Research Company Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Tranchant C Abstract Several environmental toxics are known to induce or to increase occurrence of Parkinson disease while other toxics can provoke basal ganglia necrosis and dopa resistant parkinsonism. After this introduction, the relationship between environment and parkinsonism will be illustrated by 3 short papers: interaction gene-environment, manganese induced Parkinsonism and the Caribbean Food toxins Parkinson plus syndromes. PMID: 31227125 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Conclusion: Textures of the hippocampus, precuneus and posterior cingulate cortex predicted conversion from MCI to Alzheimer disease at an earlier time point and with higher accuracy than hippocampal volume. PMID: 31228173 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
Authors: Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K Abstract INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
If we were proactive, we’ve already discussed the choices for living arrangements our loved ones would have made for themselves under differing circumstances, however, many people haven’t done this. Either way, we move forward. We need to consider whether aging-in-place is a realistic choice, with in-home care agencies providing care, or if our loved one will be safer living in a nursing home. Understand that even if you had the conversation earlier, you may have to go against their wishes. View the slideshow on HealthCentral to learn more about what you should consider before placing someone in ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Doty RL. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate. Lancet Neurol 2017; 16: 478 –88—In figure 1, the legend for panel 1B contained additional definitions. These definitions have now been removed and the legend states: “bs=basal cell undergoing mitosis. d=degenerative cell. lp=lamina propria. n=collection of axons within an ensheathing cell.” Referencing errors in the Ai r pollution and smoking section have also been corrected. The corrected sentences now state “Air pollution might be a risk factor for mild cognitive impairment,88 Alzheimer's ...
Source: Lancet Neurology - Category: Neurology Tags: Corrections Source Type: research
It should come as no surprise that optimistic thinking is, for the most part, better for one’s health than negative thinking. In fact, negative thinking has been connected to poor health for some time. A recent study confirms what was previously suspected, linking optimistic thinking to the preservation of memory and good judgement. Both of those traits bode well for staving off, if not preventing, Alzheimer’s disease. Research conducted by the University of Michigan has linked an optimistic outlook to taking better care of ourselves overall, which may explain the effect that optimism has on Alzheimer&rsqu...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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