Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients
Conclusions: This study highlights that MMP-9 or CUBN-SNPs may exert effects on risk of susceptibility to DN or ESRD. We provide novel evidence on genetic susceptibility for macroangiopathy in patients with a missense variant of CUBN (Ile2984Val) in patients with T2D.Nephron
Publication date: Available online 18 February 2019Source: Life SciencesAuthor(s): Xuyang Wang, Jinyu Pan, Hui Liu, Mingjun Zhang, Dian Liu, Lu Lu, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang AnAbstractAimsAbsent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its potential molecular mechanism.Main methodsSprague-Dawley rats were randomly divided into 4 groups: Control,...
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
Condition: Transition Intervention: Other: Transition classes Sponsor: Milton S. Hershey Medical Center Recruiting
Condition: Peripheral Arterial Disease Interventions: Drug: Carnosine; Drug: Placebo Sponsors: Monash University; Monash Health Not yet recruiting
Conditions: Weight Loss; PreDiabetes Interventions: Device: CGM; Other: Dietitian Sponsors: Stanford University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting
ConclusionsGDM/GH predict diabetes and hypertension in couples as a unit underscoring the concept of shared couple risk. These findings may help foster couple collaboration for cardiovascular risk reduction in the household
This study investigates whether resveratrol (RSV) plays a regulatory role by SphK1/S1P2 pathway in MCs proliferation and inflammation under high glucose condition. Herein, we found that RSV inhibited MCs proliferation and attenuated high glucose (HG)-induced FN, TGF-β1, ICAM-1, iNOS, SphK1 and S1P2 expression and inhibited SphK1 activity andS1P production, which was also in accordance with MCs transfected with wild-type SphK1WT plasmid. Furthermore, RSV remarkably reduced AP-1 and NF-κB activation. Overall, these results indicated that RSV could be a potential and valuable resource of natural compounds for DN tr...
DiabetesMine demystifies the FDA's new classification of " interoperable " insulin pumps.
Research, published in the Journal of Diabetes Investigation, suggests that adult type-2 diabetes patients have low natural-killer cell activity.Healio
Research, published inNutrition,Metabolism and Cardiovascular Diseases, suggests that non-alcoholic fatty liver disease increases diabetes risk in non-obese adults.Healio