A Change of Heart: Perspectives on Patient Care and Technology

Bryon Moore has had a rich and varied career in EMS. He became an EMT in 1979 and received paramedic training at the fabled UCLA Daniel Freeman School for Paramedicine in 1982. He went on to be a paramedic in several systems before becoming the Northern California Clinical Coordinator for American Medical Response (AMR). Bryon then was attracted to helping develop and bring new resuscitation technology to market, working for a variety of medical device companies and launching new products globally. He’s currently VP of EMS Market Development for Defibtech, a company owned by Nihon Kohden, a leading medical device manufacturer. In 2009, Bryon fell ill from a virus that irreversibly damaged his heart. A heart transplant saved his life—and changed his perspective on life.Q: What originally attracted you to EMS? I was allegedly speeding in my '67 GTO on the way to classes at my local junior college. While fighting that ticket, my fellow court attendee talked about his progress toward a degree in fire science. Being 18, I thought it sounded cool, so I got my EMT certification and joined the fire department as a “part-paid” firefighter. Before I knew it, I was deep into an industry that I still love, nearly 40 years later. I really wanted to understand the “why” of what I was being taught in EMT II school. I was full of questions: Why give that many milligrams? Why is that drug the standard? And when I explained this frustration to a buddy, ...
Source: JEMS Special Topics - Category: Emergency Medicine Authors: Tags: EMS Insider Exclusive Articles Administration and Leadership Source Type: news

Related Links:

In this study we describe 2 cases of successful adult DCD HT performed at our institution using an original protocol.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Featured papers Source Type: research
AbstractPurposeIntralipid® (ILE), a clinically used lipid emulsion, reduces ischemia-reperfusion (IR) injury in healthy and infarct-remodelled rat hearts. We tested whether ILE is also cardioprotective in large porcine hearts in the context of the donation after circulatory death (DCD) model, where human hearts are procured for transplantation after cardiac arrest and thus are exposed to significant IR injury.MethodsAfter induction of anesthesia, surgical preparation, termination of ventilator support, and cardiac arrest, hearts of female pigs were procured following a 15 min standoff period, with an optimized normokal...
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the k...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 24 April 2019Source: Life SciencesAuthor(s): Hongwen Lan, Yunshu Su, Yakun Liu, Cheng Deng, Jing Wang, Taiqiang Chen, Kouevidjin Ekue Dodzi Jules, Jackson Ferdinand Masau, Huiling Li, Xiang WeiAbstractAimsThe shortage of donor hearts could be alleviated with the use of the allografts from donation after circulatory death (DCD). Here, we evaluated the protective effect of melatonin on myocardial ischemia/reperfusion (MI/R) injury in a DCD heart model after ex vivo perfusion.Main methodsDonor hearts were harvested from DCD model rats pre-treated with or without melatonin and subjected to 30...
Source: Life Sciences - Category: Biology Source Type: research
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Anna M. D. Watson1,2*, Eleanor A. M. Gould2, Sally A. Penfold2, Gavin W. Lambert2,3, Putra Riza Pratama2, Aozhi Dai1, Stephen P. Gray2, Geoffrey A. Head2† and Karin A. Jandeleit-Dahm1,2† 1Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia 2Baker Heart and Diabetes Institute, Melbourne, VIC, Australia 3Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, Swinburne University of Technology, Hawthorn, VIC, Australia Patients with diabetic hypertensive nephropathy have accelerated ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co-inhibitor...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Just over 50  years ago, the first heart transplant was performed. Long-term survival was uncommon until the advent of cyclosporine (INN ciclosporin) nearly 35 years ago. Since then, there have been many changes in the field of heart transplantation, yet primary graft dysfunction (PGD) persists and is a signif icant cause of early death after heart transplantation. In patients with PGD, the cause of death is often multiorgan failure resulting from the poor perfusion of the peripheral organs. In patients with PGD, the primary goal is to support the hemodynamics until the heart recovers so that multiorgan f ailure does not occur.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
Abstract Ventricular assist devices (VADs) are an important technological development for patients with end-stage heart failure, and approximately 50% of these patients require various additional cardiac procedures. Here we presente the case of a patient suffering from severe aortic insufficiency, aortic root dilatation, and an ascending aortic aneurysm with end-stage decompensated heart failure. We performed the Bentall procedure combined with a left VAD implantation during the same session. The postoperative period was uneventful for this patient, and he was discharged on the 32nd postoperative day. The heart failure sym...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
More News: Cardiology | Environmental Health | Eyes | Heart | Heart Transplant | Hospitals | Legislation | Medical Devices | Perfusion | Science | Training | Transplant Surgery | Transplants | Universities & Medical Training