Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice

ConclusionThe present study indicates that GQT extract can ameliorate CPT-11 induced gut toxicity in mice and improve CPT-11 efficacy in colorectal cancer treatment.Graphical abstractA bioactive herbal extract derived from a classic traditional Chinese medicine formula, Gegen Qinlian Decoction, was screened via macroporous resin, characterized by UPLC analysis, and investigated to impair gut-toxicity induced by CPT-11.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research