Glypican 3 Expression in Pediatric Malignant Solid Tumors

Conclusion Most cases of hepatoblastoma and yolk sac tumor, and some cases of other tumors were found to express GPC3 either histologically or serologically. On the other hand, GPC3 was physiologically expressed during the fetal and neoinfantile period under 1 year of age. Although, more preliminary data and experience are required, patients older than 1 year that show a positive finding for GPC3 are considered to be appropriate candidates to receive the new immunotherapy using GPC3 peptide vaccination.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text

Source: European Journal of Pediatric Surgery - October 26, 2014 Category: Surgery Authors: Kinoshita, YoshiakiTanaka, SakuraSouzaki, RyotaMiyoshi, KinaKohashi, KenichiOda, YoshinaoNakatsura, TetsuyaTaguchi, Tomoaki Tags: Original Article Source Type: research