Innocent Children in the Syrian Civil War
Conclusion War affects not only the battlefield, but also the neighboring countries in many aspects such as medical, social, and economic. Hollow organ injuries are the most common intraabdominal pathologies. Delayed intervention is associated with increase mortality and morbidity. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 18, 2019 Category: Surgery Authors: Çelikkaya, Mehmet Emin At ıcı, Ahmet EL, Çigdem Ak çora, Bülent Tags: Original Article Source Type: research

Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study
Conclusion In conclusion, it appears that LET is superior to conventional anesthesia including mepivacaine infiltration in the pediatric emergency departments. Pretreatment with LET is significantly less painful but equally effective. Hence, we recommend LET as a topical anesthetic in the pediatric emergency department. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 18, 2019 Category: Surgery Authors: K önigs, Ingo Wenskus, Julia Boettcher, Johannes Reinshagen, Konrad Boettcher, Michael Tags: Original Article Source Type: research

Potential Benefits of Laparoscopic Repair of Duodenal Atresia: Insights from a Retrospective Comparative Study
Conclusion Patients undergoing laparoscopic CDO repair at our institution benefited from shorter time to full enteral feeds, and reduced the need for PN as well as postoperative pain medication. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: Sidler, Martin Djendov, Florin Curry, Joe I. Blackburn, Simon Giuliani, Stefano Eaton, Simon Mullassery, Dhanya Cross, Kate M. De Coppi, Paolo Tags: Original Article Source Type: research

“Tuft Cells”: A New Player in Hirschsprung's Disease
Eur J Pediatr Surg DOI: 10.1055/s-0039-1700549 Introduction “Tuft” cells, also known as brush or caveolated cells, are characteristically fusiform shaped, with a distinct apical “tuft” of microvilli extending into the lumen. Double cortin-like kinase 1 (DCLK1) is a microtubule kinase and is a specific marker of intestinal tuft cells. DCLK1-positive tuft cells have been shown to play a key role in gastrointestinal chemosensation, inflammation, and neurotransmission. DCLK1 and Choline acetyltransferase (ChAT), the enzymes responsible for acetylcholine production, are reported to be coexpressed...
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: O'Donnell, Anne Marie Nakamura, Hiroki Puri, Prem Tags: Original Article Source Type: research

CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells
Conclusion In our study, the hypoxic environment induced by CO2 exposure does not affect the expression of critical biomarkers of NB aggressiveness, such as N-Myc, VEGF, and MMP-2, in human SH-SY5Y NB cells without N-Myc amplification. These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to evaluate these effects in others in vitro and in vivo models. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: Montalto, Angela Simona Curr ò, Monica Russo, Tiziana Ferlazzo, Nadia Caccamo, Daniela Ientile, Riccardo Romeo, Carmelo Impellizzeri, Pietro Tags: Original Article Source Type: research

Asthma Medication Use in Congenital Diaphragmatic Hernia Survivors: A Retrospective Population Level Data Analysis
Conclusion A history of CDH is associated with higher rates of inhaled bronchodilator prescriptions, inhaled steroid prescriptions, and asthma-related physician visits from 0 to 5 years of age compared with age-matched controls. However, this difference resolves by 5 to 10 years of age. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: Levesque, Matthew Lum Min, Suyin A. Morris, Melanie I. Shawyer, Anna C. Keijzer, Richard Tags: Original Article Source Type: research

Accelerated Intestinal Epithelial Cell Turnover Correlates with Stimulated BMP Signaling Cascade following Intestinal Ischemia –Reperfusion in a Rat
Eur J Pediatr Surg DOI: 10.1055/s-0039-1700550 Introduction Bone morphogenetic proteins (BMPs) are a family of proteins that regulate proliferation and differentiation of intestinal epithelial cells. The purpose of this study was to evaluate the role of BMP signaling following intestinal ischemia–reperfusion (IR) in a rat model. Materials and Methods Male Sprague-Dawley rats were divided into four experimental groups: Sham-24 and Sham-48 rats underwent laparotomy and were sacrificed 24 or 48 hours later, respectively; IR-24 and IR-48 rats underwent occlusion of superior mesenteric artery and po...
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: Ben-Shahar, Yoav Abassi, Zaid Kreizman Shefer, Hila Pollak, Yulia Bhattacharya, Udayan Sukhotnik, Igor Tags: Original Article Source Type: research

Multicenter Study of 342 Anorectal Malformation Patients: Age, Gender, Krickenbeck Subtypes, and Associated Anomalies
Conclusion Our study provides important insights about ARM subtypes, gender distribution and associated anomalies based on Krickenbeck classification especially from Bangladesh and Iran. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 26, 2019 Category: Surgery Authors: Banu, Tahmina Karim, Anwarul Adel, Maryam Ghavami Lakhoo, Kokila Aziz, Tasmiah Tahera Das, Arni Sharmeen, Nugayer Yapo, Benjamin Ferdous, Kazi Md Noor-ul Kabir, Kh Ahasanul Zahid, Mirza Kamrul Ford, Kathryn Ahsan, Md Qumrul Akter, Mastura Alam, Md Afruzul Tags: Original Article Source Type: research

Novel Risk Score for Fetuses with Congenital Diaphragmatic Hernia Based on Ultrasound Findings
Eur J Pediatr Surg DOI: 10.1055/s-0039-1698768 Introduction We aimed to establish and validate a risk score for fetuses with congenital diaphragmatic hernia (CDH) using only prenatal ultrasound findings. Material and Methods Derivation (2011–2016, n = 350) and validation (2006–2010, n = 270) cohorts were obtained from a Japanese CDH study group database. Using a logistic regression analysis, we created a prediction model and weighted scoring system from the derivation dataset and calculated the odds ratio of an unsatisfactory prognosis (death within 90 days of life or...
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Terui, Keita Nagata, Kouji Hayakawa, Masahiro Okuyama, Hiroomi Amari, Shoichirou Yokoi, Akiko Masumoto, Kouji Urushihara, Naoto Okazaki, Tadaharu Inamura, Noboru Toyoshima, Katsuaki Uchida, Keiichi Furukawa, Taizo Okawada, Manabu Sato, Yasunori Usui, Nori Tags: Original Article Source Type: research

Epidural versus PCA Pain Management after Pectus Excavatum Repair: A Multi-Institutional Prospective Randomized Trial
Eur J Pediatr Surg DOI: 10.1055/s-0039-1697911 Introduction Postoperative pain control remains the primary reason for inpatient stay after minimally invasive repair of pectus excavatum. In a previous study, our group reported that early pain control was better in patients managed with a thoracic epidural, while late pain control was better in patients managed with patient-controlled analgesia (PCA). After revising our epidural transition and modifying the PCA protocol, we conducted a multi-institutional prospective randomized trial to evaluate these two pain control strategies. Materials and Methods Patient...
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Sujka, Joseph A. Dekonenko, Charlene Millspaugh, Daniel L. Doyle, Nichole M. Walker, Benjamin J. Leys, Charles M. Ostlie, Daniel J. Aguayo, Pablo Fraser, Jason D. Alemayehu, Hanna Peter, Shawn D. St. Tags: Original Article Source Type: research

Mechanical versus Chemical Pleurodesis after Bullectomy for Primary Spontaneous Pneumothorax: A Systemic Review and Meta-Analysis
Conclusion Chemical pleurodesis is superior to mechanical pleurodesis following bullectomy for PSP in reducing hospital stay and recurrence rate. However, more RCTs with longer follow-up are necessary to demonstrate the benefit of chemical pleurodesis for PSP. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Sim, Sarah Kher Ru Nah, Shireen Anne Loh, Amos Hong Pheng Ong, Lin Yin Chen, Yong Tags: Original Article Source Type: research

Can Free Carnitine or Bilirubin in Blood Be Used in Neonatal Screening for Biliary Atresia?
Conclusion In free carnitine, DB, and CBMS/TBMS tests, blood concentrations are elevated in all infants with BA. However, they may not be elevated while they are newborns. These tests will result in high false negatives or positives. Thus, they should not be used as newborn screening tests for BA due to their lower sensitivity and specificity. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Gong, Zhenhua Wu, Yibo Zheng, Lulu Chen, Licai Lv, Zhibzo Tags: Original Article Source Type: research

Surgical Management of Esophageal Achalasia in Pediatrics: A Systematic Review
Eur J Pediatr Surg DOI: 10.1055/s-0039-1697958 Introduction There are no evidence-based guidelines on the surgical management of esophageal achalasia (OA) in children. This can be a challenging condition with significant physical and psychological morbidity. Our aim was to identify the most common management modalities and their outcomes. Materials and Methods A systematic review was performed through a literature search of health care databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, aiming at identifying pediatric series discussing the diagnosi...
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Goneidy, Ayman Cory-Wright, James Zhu, Limeng Malakounides, Georgina Tags: Original Article Source Type: research

Investigation of Bosentan's Effects on Pulmonary Contusion Created by Blunt Thoracic Trauma in Rats
Eur J Pediatr Surg DOI: 10.1055/s-0039-1697908 Introduction Bosentan is an endothelin-1 receptor antagonist with anti-inflammatory, antioxidant, and antiproliferative effects. We aimed to evaluate its effects on lung tissue in a pulmonary contusion (PC) model. Materials and Methods The rats were randomly divided into five groups: PC3: PC evaluated on the 3rd day (n = 8), PC-B3: PC enteral bosentan 100 mg/kg/day, for 3 days (n = 8), PC7: PC evaluated on the 7th day (n = 7), PC-B7: PC 7 days bosentan 100 mg/kg/day, for 7 days (n = 8), C: co...
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Gercel, Gonca Aksu, Burhan Ozkanli, Seyma Uzun, Hafize Aksu, Feyza Ozatman, Erdem Durakba şa, Çiğdem Ulukaya Tags: Original Article Source Type: research

The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease
Conclusion The use of anti-TNF-α in pediatric CD patients within the 90 days prior to their abdominal surgery was not associated with an increased risk of 30-day postoperative complications. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Dotlacil, Vojtech Bronsky, Jiri Hradsky, Ondrej Frybova, Barbora Coufal, Stepan Skaba, Richard Rygl, Michal Tags: Original Article Source Type: research

Mitochondrial DNA: A Biomarker of Disease Severity in Necrotizing Enterocolitis
Eur J Pediatr Surg DOI: 10.1055/s-0039-1697910 Introduction There is a need to develop sensitive markers to diagnose or monitor the severity of intestinal damage in necrotizing enterocolitis (NEC). Mitochondrial deoxyribonucleic acid (mtDNA) is increased in the intestine and blood of adults in response to intestinal ischemia and can trigger secondary organ damage. We hypothesize that mtDNA is increased during experimental NEC and that mtDNA levels are correlated to the degree of intestinal injury. Materials and Methods NEC was induced in C57BL/6 mice (n = 18) (approval: 44032) by gavage feedin...
Source: European Journal of Pediatric Surgery - October 10, 2019 Category: Surgery Authors: Bindi, Edoardo Li, Bo Zhou, Haitao Janssen Lok, Maarten Alganabi, Mashriq Angotti, Rossella Pierro, Agostino Tags: Original Article Source Type: research

Thoracoscopic Resection of Congenital Lung Malformation: Looking for the Right Preoperative Assessment
Conclusion MRI proved to be a reliable diagnostic investigation for CLM with high sensitivity and specificity. Early MRI in spontaneous sleep without contrast and preoperative contrast CT scan is a valuable preoperatory assessment. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 6, 2019 Category: Surgery Authors: Macchini, Francesco Borzani, Irene Cavalli, Silvia Morandi, Anna D'Angelo, Ida Daniela Zanini, Andrea Ferrari, Carlo Ichino, Martina Leva, Ernesto Tags: Original Article Source Type: research

Clinical Factors in Trunk Capillary Malformations in the Neonate: When to Suspect Other Associated Malformations? A Case –Control Study
The objective of this study is to describe the clinical patterns in the neonate that allow us to differentiate sporadic CMs from those associated with other vascular malformations. Materials and Methods A case–control study was performed in neonates with CM located in the trunk, followed at our institution between 2008 and 2018. The patients were divided into two groups: group A (cases: CM associated with VM or LM) and group B (controls: sporadic CM without associated malformations). Demographic and clinical variables collected in the clinical history were evaluated (color, location, multifocality, bilaterali...
Source: European Journal of Pediatric Surgery - October 6, 2019 Category: Surgery Authors: Delgado-Miguel, Carlos Vicente, Miriam Serrano-Mu ñoz, Antonio Jesus Miguel-Ferrero, Miriam Diaz, Mercedes Triana, Paloma L ópez-Gutiérrez, Juan Carlos Tags: Original Article Source Type: research

Experimental Models for Novel Therapies in Neonatal Surgery: Translational Approaches
Eur J Pediatr Surg 2019; 29: 315-316 DOI: 10.1055/s-0039-1695798 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 18, 2019 Category: Surgery Authors: Zani, Augusto Sbragia, Louren ço Tags: Editorial Source Type: research

Treatment of Closed Tibia Shaft Fractures in Children: A Systematic Review and Meta-Analysis
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693991Tibia fractures are among the most common long-bone fractures in children. Despite this, there is no current consensus on the optimal treatment strategy for closed displaced tibia shaft fractures in the pediatric patient population. The aim of this study is to compare the reported complications and outcomes of reduction and cast immobilization versus flexible intramedullary nailing in the treatment of pediatric tibia shaft fractures. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement when conducting and reporting this prospecti...
Source: European Journal of Pediatric Surgery - August 22, 2019 Category: Surgery Authors: Stenroos, Antti Puhakka, Jani Nietosvaara, Yrj änä Kosola, Jussi Tags: Review Article Source Type: research

Total Colonic Hirschsprung's Disease: The Hypermotility and Skin Rash Protocol
Conclusion TCHD patients who underwent definitive pull through had nine high incidence of multiple stool, perineal rash, and low growth. With the implementation of bowel management care to slow the stools and a perineal skin protocol to treat the skin, we believe that these symptoms can be minimized even in patients who are not toilet trained. Since the implementation of this protocol, we have changed our practice to perform the pull through in such patients between the age of 6 and 18 months. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  ...
Source: European Journal of Pediatric Surgery - August 20, 2019 Category: Surgery Authors: Sanchez, Alejandra Vilanova Ivanov, Monica Halleran, Devin R. Wagner, Andrea Reck-Burneo, Carlos Albert Ruth, Brenda FIsher, Meghan Ahmad, Hira Weaver, Laura Nash, Onnalisa Buker, Danielle Rentea, Rebecca Maria Hoover, Erin Maloof, Tassiana Wood, Richard Tags: Review Article Source Type: research

Animal Models of Hirschsprung's Disease: State of the Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1694745Hirschsprung's disease (HSCR) is caused by incomplete colonization of enteric neural crest-derived cell (ENCC) in the bowel, the failure of ENCCs to proliferate, differentiate, and migrate leads to an absence of enteric neurons in the distal colon, resulting in colonic motility dysfunction. Various animal models of HSCR have been important in the understanding of the anatomy and pathophysiology of the disease and in the discovery of genes involved in HSCR. Four types of HSCR animal models have been developed: teratogen-induced, surgically created, naturally occurring models, an...
Source: European Journal of Pediatric Surgery - August 20, 2019 Category: Surgery Authors: Fujiwara, Naho Nakazawa-Tanaka, Nana Yamataka, Atsuyuki Tags: Review Article Source Type: research

Gastroschisis: State of the Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1694746The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs...
Source: European Journal of Pediatric Surgery - August 19, 2019 Category: Surgery Authors: Sbragia, Louren ço Figueira, Rebeca Lopes Miura da Costa, Karina Volpe, F ábio Perecim Tags: Review Article Source Type: research

Anorectal Malformation: State of the Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1694743The embryology of anorectal malformation (ARM) is a controversial issue. The study in humans is difficult due to the scarcity of fetuses with this anomaly. Therefore, ARM animal models, naturally obtained or induced by drugs, have been employed to understand physiopathology and possible treatments. Pigs, rabbits, rats, and mice have been employed as animal models. Additionally, many drugs have been used with this purpose: Etretinate, Ethylenethiourea, and Adriamycin. The animal more frequently used is the rat because of good reproducibility, low cost, and easy handling. Pig is ...
Source: European Journal of Pediatric Surgery - August 19, 2019 Category: Surgery Authors: Martins, Jos é Luiz Macedo, Maur ício Montero, Edna Frasson de Souza Tags: Review Article Source Type: research

Necrotizing Enterocolitis: State of the Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693994Necrotizing enterocolitis (NEC) is a devastating intestinal disease that continues to have high morbidity and mortality among preterm neonates, despite medical advancements in neonatology and neonatal care. To investigate the pathogenesis of the disease and explore novel form of treatment, a variety of experimental models of NEC have been developed and used by various investigators. These experimental models range from in vitro evaluation of intestinal epithelial cells and intestinal organoids to in vivo models of the disease in neonatal mice, rats, and piglets. Most recently, ...
Source: European Journal of Pediatric Surgery - August 19, 2019 Category: Surgery Authors: Ganji, Niloofar Li, Bo Lee, Carol Filler, Rachel Pierro, Agostino Tags: Review Article Source Type: research

Esophageal Atresia: State of the Art in Translating Experimental Research to the Bedside
This article will review the available experimental treatment options with a focus on novel techniques. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - August 19, 2019 Category: Surgery Authors: Bruns, Nicholas E. Glenn, Ian C. Ponsky, Todd A. Tags: Review Article Source Type: research

Translational Research in Biliary Atresia: News from Mice and Men
This article presents a review of the literature on available BA animal models and gives a glimpse of future developments. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - August 14, 2019 Category: Surgery Authors: Madadi-Sanjani, Omid Petersen, Claus Tags: Review Article Source Type: research

Congenital Diaphragmatic Hernia: State-of-the-Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693993Congenital diaphragmatic hernia (CDH) is a devastating disease that still carries a high mortality and morbidity rate. Poor outcomes for fetuses and infants with CDH are mainly related to pulmonary hypoplasia (PH) and pulmonary vascular remodeling that leads to pulmonary hypertension (PHTN). Over the last five decades, research efforts have focused on modeling CDH not only to study the pathophysiology of the diaphragmatic defect, pulmonary hypoplasia, and pulmonary hypertension, but also to identify therapies that would promote lung growth and maturation, and correct vascular r...
Source: European Journal of Pediatric Surgery - July 31, 2019 Category: Surgery Authors: Antounians, Lina Figueira, Rebeca Lopes Sbragia, Louren ço Zani, Augusto Tags: Review Article Source Type: research

Liver Organoids Generated from Mice with Necrotizing Enterocolitis Have Reduced Regenerative Capacity
Conclusion We report a novel technique to generate liver organoids during NEC. These organoids are characterized by reduced progenitor cells, reduced proliferation, and overall impaired regenerative capacity. Liver progenitor cells are important targets to prevent liver damage in NEC and promote recovery. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - July 31, 2019 Category: Surgery Authors: Miyake, Hiromu Lee, Carol Seo, Shogo Li, Bo Pierro, Agostino Tags: Original Article Source Type: research

Gravitational Autoreposition for Staged Closure of Omphaloceles
Conclusion GRAVITAS is a feasible method for staged closure of large omphaloceles when successful primary closure is deemed questionable. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - July 25, 2019 Category: Surgery Authors: Uecker, Marie Petersen, Claus Dingemann, Carmen Fortmann, Caroline Ure, Benno M. Dingemann, Jens Tags: Original Article Source Type: research

Lactoferrin Reduces Necrotizing Enterocolitis Severity by Upregulating Intestinal Epithelial Proliferation
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693728 Introduction Necrotizing enterocolitis (NEC) is a devastating intestinal illness in premature infants characterized by severe intestinal inflammation. Despite medical interventions, NEC mortality remains alarmingly high, which necessitates improved therapies. Lactoferrin is among the most abundant proteins in human milk and has important immunomodulatory functions. While previous studies have indicated protective effects of lactoferrin against neonatal sepsis and NEC, the underlying mechanism remains unclear. We hypothesize that lactoferrin downregulates inflammation a...
Source: European Journal of Pediatric Surgery - July 25, 2019 Category: Surgery Authors: Liu, Jia Zhu, Haitao T. Li, Bo Robinson, Shaiya C. Lee, Carol O'Connell, Joshua S. Bindi, Edoardo Zheng, Shan Sherman, Philip M. Pierro, Agostino Tags: Original Article Source Type: research

Ultrasound Monitoring after Pelvis-Sparing Dismembered Pyeloplasty: High Sensitivity and Low Specificity for the Success of Operation
Conclusion To our knowledge, this is the first study evaluating the efficacy of ultrasound measurements to identify patients with decompensated urinary drainage during early follow-up after pyeloplasty with pelvis sparing. Post- versus preoperative decrease in renal pelvis diameter appears to be sufficient to rule out recurrence of obstruction. Renal scan seems to be indicated only in cases with post- versus preoperative increase in the APD of the renal pelvis on ultrasound. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract &nbs...
Source: European Journal of Pediatric Surgery - July 25, 2019 Category: Surgery Authors: Kiblawi, Rim Kuebler, Joachim F. Petersen, Claus Ure, Benno M. Hofmann, Alejandro D. Tags: Original Article Source Type: research

Clinical Factors Affecting Condition-Specific Quality-of-Life Domains in Pediatric Patients after Repair of Esophageal Atresia: The Swedish-German EA-QOL Study
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693729 Introduction We aimed to identify clinical factors affecting condition-specific health related quality of life (HRQOL) domains in children born with esophageal atresia (EA). This can facilitate preventive care to risk groups of HRQOL impairments. Materials and Methods A total of 124 Swedish and German families of EA children answered the validated EA-QOL questionnaires (response rate 68%), for evaluation of three HRQOL domains in children 2 to 7 years old (53 parents) and four HRQOL domains in children 8 to 17 years old (62 children/71 parents). Clinical data w...
Source: European Journal of Pediatric Surgery - July 25, 2019 Category: Surgery Authors: Dellenmark-Blom, Michaela Quitmann, Julia Dingemann, Jens Witt, Stefanie Ure, Benno M. Bullinger, Monika J önsson, Linus Gatzinsky, Vladimir Dingemann, Carmen Tags: Original Article Source Type: research

ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Diagnostics, Preoperative, Operative, and Postoperative Management
Conclusion Participants of the conference reached significant consensus on the management of patients with EA/TEF. The consensus may facilitate standardization and development of generally accepted guidelines. The conference methodology may serve as a blueprint for further conferences on the management of congenital malformations in pediatric surgery. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - July 2, 2019 Category: Surgery Authors: Dingemann, Carmen Eaton, Simon Aksnes, Gunnar Bagolan, Pietro Cross, Kate M. Decoppi, Paolo Fruithof, JoAnne Gamba, Piergiorgio Husby, Steffen Koivusalo, Antti Rasmussen, Lars Sfeir, Rony Slater, Graham Svensson, Jan F. Van der Zee, David C. Wessel, Lucas Tags: Original Article Source Type: research

Neuromuscular Blocking Agents and Rapid Sequence Induction for Laparoscopic Pyloromyotomy: Impact on Time to Extubation and Perioperative Complications
Conclusion The use of succinylcholine, cisatracurium, or no NMBA at induction of anesthesia in infants undergoing laparoscopic pyloromyotomy had no statistically significant effect on time until extubation and complication rates. A modified RSI seems to be safe and effective in these cases. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - June 26, 2019 Category: Surgery Authors: Swenker, Dominique van der Knijff-van Dortmont, Anna Gonzalez Candel, Antonia Keyzer-Dekker, Claudia Staals, Lonneke Tags: Original Article Source Type: research

Perioperative Complications after Kasai Hepatoportoenterostomy: Data from the Swiss National Biliary Atresia Registry
Conclusion HPE is often associated with perioperative medical complications. Lower gestational age at birth was significantly associated with more complications. Perioperative complications had no impact on overall outcome. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - June 25, 2019 Category: Surgery Authors: Calinescu, Ana M. Wilde, Jim C. H. Korff, Simona McLin, Val érie A. Wildhaber, Barbara E. Tags: Original Article Source Type: research

Interventional Radiology-Guided Procedures in the Treatment of Pediatric Solid Tumors: A Systematic Review and Meta-Analysis from the Group of Young Pediatric Surgeons of Europe
Eur J Pediatr Surg DOI: 10.1055/s-0039-1692655 Introduction The use of interventional radiology (IR) in the treatment of pediatric solid tumors has markedly increased over the last three decades. However, data on effectiveness of IR-techniques, such as embolization/ablation, are scarce. In this systematic review and meta-analysis, we examined the outcomes of IR-procedures in the treatment of solid tumors in children. Materials and Methods Using a defined search strategy, we searched for studies reporting the use of IR-techniques for pediatric solid tumors from 1980 to 2017. Reports with less than three pati...
Source: European Journal of Pediatric Surgery - June 23, 2019 Category: Surgery Authors: Zambaiti, Elisa Siles Hinojosa, Alexander Montano, Valentina Mutanen, Annika Glenisson, Mathilde Sarnacki, Sabine Franchi Abella, Stephanie Pariente, Daniele Pio, Luca Tags: Review Article Source Type: research

Malrotation in Congenital Diaphragmatic Hernia: Is It Really a Problem?
This study evaluates intestinal malrotation in CDH patients. Materials and Methods All patients with a CDH treated in a high-volume center between 2000 and 2015 were retrospectively evaluated. Demographics, gastrointestinal characteristics, surgical treatment, and abdominal outcomes (acute surgery, small bowel obstruction, and volvulus) were described. Results A total of 197 CDH patients were surgically repaired. In 76 (39%) patients, a malrotation was described at initial CDH repair, in 39 (20%) patients, a normal rotation, but 82 patients (42%) had no report on intestinal rotation. During follow-up (range...
Source: European Journal of Pediatric Surgery - June 14, 2019 Category: Surgery Authors: Heiwegen, Kim de Blaauw, Ivo van Ling, Julia Botden, Sanne M. B. I. Tags: Original Article Source Type: research

Value of Fibrinogen to Discriminate Appendicitis from Nonspecific Abdominal Pain in Preschool Children
Eur J Pediatr Surg DOI: 10.1055/s-0039-1692166 Aim The aim of this study was to assess the diagnostic value of the biomarker fibrinogen (FB), along with the markers white blood cell (WBC) count, absolute neutrophil count (ANC), and C-reactive protein (CRP), to discriminate appendicitis from nonspecific abdominal pain (NSAP) in preschool children. Materials and Methods We prospectively evaluated all children aged 540 mg/dL is associated with an increased likelihood of complicated appendicitis. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |&...
Source: European Journal of Pediatric Surgery - June 12, 2019 Category: Surgery Authors: Prada-Arias, Marcos G ómez-Veiras, Javier Salgado-Barreira, Ángel V ázquez, José Luis Montero-S ánchez, Margarita Fern ández-Lorenzo, José Ramón Tags: Original Article Source Type: research

Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes
Conclusion We identified increased lipid peroxidation, oxidative DNA damage, IMA, and NOX4 levels in children with UDT. Delay in the treatment of UDT may cause oxidative damage. That is why, according to us the antioxidant treatment may be beneficial in children with UDT. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - June 5, 2019 Category: Surgery Authors: Avci, Veli Ayengin, Kemal Alp, Hamit Hakan Tags: Original Article Source Type: research

Recurrent Ventral Curvature with Long-Term Follow-up after Transverse Preputial Island Urethroplasty
Conclusion Although the patients in our study represent only a small portion of the overall hypospadias population, it is notable that 32.5% of these patients showed recurrent VC, including 28.6% of patients with transection plus DP. We suggest long-term follow-up of hypospadias at least during adolescence or even into adulthood. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 12, 2019 Category: Surgery Authors: Wang, Chaoxu Zhang, Weiping Song, Hongcheng Tags: Original Article Source Type: research

Variations in the Detection of Anorectal Anomalies at Birth among European Cities
This study aimed to define the rate of missed ARM at birth across four United Kingdom and European Union centers. Materials and Methods All ARM cases treated at two United Kingdom tertiary centers in the past 15 years were compared with two tertiary European centers. Demographic and relevant clinical data were collected. Late diagnosis was defined as any diagnosis made after discharge from the birth unit. Factors associated with late diagnosis were explored with descriptive statistics. Results Across the four centers, 117/1,350, 8.7% were sent home from the birth unit without recognizing the anorectal anoma...
Source: European Journal of Pediatric Surgery - April 30, 2019 Category: Surgery Authors: Aldeiri, Bashar Davidson, Joseph R. Eaton, Simon Coletta, Riccardo Cardoso Almeida, Andre Long, Anna-May Knight, Marian Cross, Kate M. Chouikh, Taieb Iacobelli, Barbara Daniela Sarnacki, Sabine Bagolan, Pietro Cretolle, Celia Siminas, Sotirios Curry, Joe Tags: Original Article Source Type: research

Outcomes after Split Abdominal Wall Muscle Flap Repair for Large Congenital Diaphragmatic Hernias
Eur J Pediatr Surg DOI: 10.1055/s-0039-1687867 Background Repair of large congenital diaphragmatic hernias (CDHs) is challenging. As primary repair is not always feasible, patches are commonly used. An alternative treatment is split abdominal wall muscle flap repair, which uses vascularized autologous tissue. The aim of this study was to analyze the long-term outcome of large CDH defects undergoing split abdominal wall muscle repair. Materials and Methods This is a retrospective review (2003–2016) of large CDH treated by split abdominal wall muscle flap repair. Results In a total of 107 CDH pa...
Source: European Journal of Pediatric Surgery - April 25, 2019 Category: Surgery Authors: Molino, Jos é A. Garc ía Martínez, Laura Guill én Burrieza, Gabriela Peir ó Ibáñez, José Luís L ópez-Fernández, Sergio La ín, Ana Ruiz Campillo, Cesar Lloret Roca, Josep L ópez, Manuel Tags: Original Article Source Type: research

Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study
Conclusion In children with AA, there is a strong association between low plasma sodium concentration and perforation, a novel and not previously described finding. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - April 25, 2019 Category: Surgery Authors: Lindestam, Ulf Almstr öm, Markus Jacks, Johannes Malmquist, Pia L önnqvist, Per-Arne Jensen, Boye Lagerbon Carlstr öm, Mattias Krmar, Rafael Tomas Svensson, Jan Fredrik Norberg, Åke Fl äring, Urban Tags: Original Article Source Type: research

The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma
Eur J Pediatr Surg DOI: 10.1055/s-0039-1687869 Objective Vascular endothelial growth factor (VEGF) and its receptor act as a major contributor to lymphangioma, but their role on nonrecurrent and recurrent lymphangiomas remain unclear. We aim to investigate those factors in the generation of recurrent lymphangioma. Materials and Methods Patients diagnosed with lymphangioma from January 2005 to December 2012 in our hospital were collected and divided into nonrecurrent and recurrent lymphangiomas. The clinical characteristics including age, sex, symptoms, location, and size of lymphangioma were collected. Surg...
Source: European Journal of Pediatric Surgery - April 23, 2019 Category: Surgery Authors: Yan, Xueqiang Zheng, Nannan Xiong, Xiaoli Duan, Xufei Yang, Jun Bian, Hongqiang Zhu, Zhenchuang Xiong, Xiaofeng Chen, Xuyong Tags: Original Article Source Type: research

Thirty Years of Minimally Invasive Surgery in Children: Analysis of Meta-Analyses
Conclusion In the available MAs, the advantages of MIS seem to outnumber the disadvantages. However, for some types of procedures, MIS may have considerable disadvantages. More randomized controlled trials are required to confirm the advantage of MIS for most procedures. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - April 23, 2019 Category: Surgery Authors: Schukfeh, Nagoud Kuebler, Joachim F. Dingemann, Jens Ure, Benno M. Tags: Original Article Source Type: research

Tracheoscopic Findings and Their Impact on Respiratory Symptoms in Children with Esophageal Atresia
Conclusion Tracheomalacia tends to be present independently of surgical procedure. Tracheomalacia should be measured by tracheoscopy (in % of tracheal collapse). Patients with a tracheal collapse of>80%, a ventral pulsation, and obstructive apnea or cyanosis in combination, are at risk for life-threatening situations and further surgical treatment should be considered. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 21, 2019 Category: Surgery Authors: Fischer, Janina Balleisen, Johannes Holzki, Josef Cernaianu, Grigore Alejandre Alc àzar, Miguel D übbers, Martin Tags: Original Article Source Type: research

The Outcome of the Single Step Questionnaire in Pectus Excavatum Patients is Phase Dependent
Eur J Pediatr Surg DOI: 10.1055/s-0039-1681025 Background Pectus excavatum (PE) is the most common chest wall deformity. Patients with PE may have cosmetic complaints, restricted physical capabilities, or both and may seek surgical correction. One method to assess satisfaction after surgery is the single step questionnaire (SSQ). Although the developers state that the SSQ produces a stabile score and only needs to be used once, we hypothesized that the score may depend on point in time after surgery. Patients and Methods One hundred and eight patients from a longitudinal cohort of patients undergoing a Nuss...
Source: European Journal of Pediatric Surgery - March 1, 2019 Category: Surgery Authors: Zuidema, Wietse P. van der Steeg, Alida F. W. van der Heide, Stefan Zijp, Gerda W. van Baren, Robertine Oosterhuis, Jan W. A. van Heurn, Ernest Tags: Original Article Source Type: research

Long-Term Effectiveness of Antireflux Surgery in Esophageal Atresia Patients
Conclusion In the long term, ARP is not effective in reducing GERD as measured as Ri in EA patients. The ARP group had significantly lower weight at 1 and 7 years of age than the non-ARP group, but this was not the case at the age of 15. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 1, 2019 Category: Surgery Authors: J önsson, Linus Dellenmark-Blom, Michaela Enoksson, Oskar Friberg, Lars G öran Gatzinsky, Vladimir Sandin, Anders Abrahamsson, Kate Tags: Original Article Source Type: research

Mechanical Bowel Preparation versus No Preparation in Duhamel Procedure in Children with Hirschsprung's Disease
Conclusion For young children with HSCR who were scheduled for Duhamel operation, we had found no clear benefit of MBP. However, a multicenter randomized controlled trial is needed to more definitely determine the best preoperative approach for children with HSCR. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 27, 2019 Category: Surgery Authors: Hosseinpour, Mehrdad Ahmadi, Bahareh Etezazian, Sanaz Tags: Original Article Source Type: research