Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559884 Introduction The origin of congenital diaphragmatic hernia (CDH) is considered to lie in a malformation of the nonmuscular primordial diaphragm. It is known that fetal diaphragmatic development requires the structural integrity of its underlying mesenchymal tissue. Developmental mutations that inhibit the formation of normal diaphragmatic mesenchyme have been shown to cause CDH. FRAS1-related extracellular matrix 1 (FREM1) plays a critical role in the development of the fetal diaphragm. It has been demonstrated that a deficiency of FREM1 can lead to CDH both in human...
Source: European Journal of Pediatric Surgery - September 18, 2015 Category: Surgery Authors: Takahashi, ToshiakiFriedmacher, FlorianPuri, Prem Tags: Original Article Source Type: research

Is Routine Upper Gastrointestinal Contrast Study Necessary prior to Laparoscopic Gastrostomy Tube Placement in Children?
Conclusions We found that in children undergoing routine preoperative UGI before GT placement (1) the risk of malrotation is less than 1%; (2) the decision to perform an antireflux procedure weakly correlates with the UGI findings of GER; and (3) one in five patients without radiographic GER still underwent concomitant fundoplication with or without confirmatory pH probe study. We conclude that the practice of routine UGI before laparoscopic gastrostomy placement in children is likely unnecessary.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  | &nbs...
Source: European Journal of Pediatric Surgery - September 18, 2015 Category: Surgery Authors: Acker, Shannon N.Trinh, Becky B.Partrick, David A.Stewart, Camille L.Bensard, Denis D. Tags: Original Article Source Type: research

Evaluation of Antiseptic Use in Pediatric Surgical Units in the United Kingdom—Where Is the Evidence Base?
Conclusion A majority of pediatric surgical units and individual surgeons use Betadine in premature and below 1.5 kg infants despite this being outside the product license. There is no ideal product choice based on current evidence but surgeons must be aware of the inherent risks and benefits of each product.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 17, 2015 Category: Surgery Authors: Ng, Angela Li ChingJackson, ClaireKazmierski, Marcin Tags: Review Article Source Type: research

Effect of N-Acetylserotonin on Intestinal Recovery Following Intestinal Ischemia–Reperfusion Injury in a Rat
Conclusions Treatment with NAS prevents gut mucosal damage and inhibits programmed cell death following intestinal IR in a rat.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 17, 2015 Category: Surgery Authors: Shahar, Yoav BenSukhotnik, IgorBitterman, NirPollak, YuliaBejar, JacobChepurov, DmitriyCoran, ArnoldBitterman, Arie Tags: Original Article Source Type: research

The Endoscopic Morphological Features of Congenital Posterior Urethral Obstructions in Boys with Refractory Daytime Urinary Incontinence and Nocturnal Enuresis
Conclusions PUV type 1 encompassed lesions with a spectrum of obstructions ranging from severe to mild, with mild types whose main obstructive lesion existed at the anterior wall of urethra occurring most frequently in boys with refractory daytime urinary incontinence and/or nocturnal enuresis.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 17, 2015 Category: Surgery Authors: Nakamura, ShigeruHyuga, TaijuKawai, ShinaKubo, TaroNakai, Hideo Tags: Original Article Source Type: research

Portal Cavernoma in the Era of Mesoportal Shunt (Rex) and Liver Transplant in Children
Conclusions The MPS is the technique of choice in EHPVO for idiopathic thrombosis as well as secondary to LT. Not all cases are favorable for MPS, so the surgeon must consider the possibility of alternative techniques for EHPVO. The results in terms of shunt patency are much better in idiopathic cavernoma that posttransplant patients.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 17, 2015 Category: Surgery Authors: Chocarro, GloriaJunco, Paloma TrianaDominguez, EvaAmesty, María VirginiaCerezo, Vanesa NuñezHernandez, FranciscoMurcia, JavierTovar, Juan AntonioLopez Santamaria, Manuel Tags: Original Article Source Type: research

Evaluation of Antiseptic Use in Pediatric Surgical Units in the United Kingdom —Where Is the Evidence Base?
Conclusion A majority of pediatric surgical units and individual surgeons use Betadine in premature and below 1.5 kg infants despite this being outside the product license. There is no ideal product choice based on current evidence but surgeons must be aware of the inherent risks and benefits of each product.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - September 17, 2015 Category: Surgery Authors: Ng, Angela Li Ching Jackson, Claire Kazmierski, Marcin Tags: Review Article Source Type: research

Bridging the Gap―More than Surgery Only
Eur J Pediatr Surg 2015; 25: 311-311DOI: 10.1055/s-0035-1563707Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - August 31, 2015 Category: Surgery Authors: Wijnen, Rene M. H.Ure, Benno Tags: Editorial Source Type: research

Dysphagia in Children with Esophageal Atresia: Current Diagnostic Options
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559818Dysphagia or swallowing disorder is very common (range, 15–52%) in patients with esophageal atresia. Children present with a wide range of symptoms. The most common diagnostic tools to evaluate esophageal dysphagia, such as upper barium study and manometry, aim to characterize anatomy and function of the esophageal body and the esophagogastric junction (EGJ). Using these technologies, a variety of pathological motor patterns have been identified in children with esophageal atresia. However, the most challenging part of diagnosing patients with esophageal dysphagia lies in ...
Source: European Journal of Pediatric Surgery - August 26, 2015 Category: Surgery Authors: Rayyan, MaissaAllegaert, KarelOmari, TaherRommel, Nathalie Tags: Review Article Source Type: research

Feeding and Swallowing Disorders in Esophageal Atresia Patients: A Review of a Critical Issue
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559819Feeding and swallowing disorders are commonly seen in clinical practice in infants and children treated for esophageal atresia with or without tracheoesophageal fistula. Nevertheless, only few authors have addressed these issues. This review aims to describe the feeding and swallowing disorders encountered, focusing on pathophysiology, normal development of swallowing and feeding abilities, and possible rehabilitation therapies to prevent or correct these disorders.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |&n...
Source: European Journal of Pediatric Surgery - August 26, 2015 Category: Surgery Authors: Conforti, AndreaValfré, LauraFalbo, MartinaBagolan, PietroCerchiari, Antonella Tags: Review Article Source Type: research

Bridging the Gap in the Repair of Long-Gap Esophageal Atresia: Still Questions on Diagnostics and Treatment
Eur J Pediatr SurgDOI: 10.1055/s-0035-1562926Long-gap esophageal atresia remains a complex surgical problem fraught with complications and poor outcomes in many patients. This review covers the techniques and strategies currently used to address this congenital anomaly. The techniques covered include preservation of the native esophagus, esophageal elongation techniques, esophageal replacement, and evolving work on tissue engineering.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journa...
Source: European Journal of Pediatric Surgery - August 24, 2015 Category: Surgery Authors: von Allmen, DanielWijnen, Rene M. H. Tags: Review Article Source Type: research

Screening and Surveillance in Esophageal Atresia Patients: Current Knowledge and Future Perspectives
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559817Esophageal atresia (EA) is a rare congenital anomaly. Enhanced operative techniques and intensive care treatment have improved survival among children with repaired EA (range, 93–95%). Many (up to 67%) suffer from gastroesophageal reflux (GER). The high incidence of GER and improved survival among EA patients raises concerns about an increased risk of developing Barrett esophagus (BE) and esophageal cancer. This review provides an overview of the prevalence of esophagitis, BE, and esophageal cancer in EA patients and outlines suggestions for future research. A literature s...
Source: European Journal of Pediatric Surgery - August 24, 2015 Category: Surgery Authors: Vergouwe, Florence W. T.IJsselstijn, HannekeWijnen, René M. H.Bruno, Marco J.Spaander, Manon C. W. Tags: Review Article Source Type: research

Eosinophilic Esophagitis in Children with Esophageal Atresia
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559815Recent studies have reported a higher prevalence of eosinophilic esophagitis in children with esophageal atresia. Under recognition of eosinophilic esophagitis in these patients may lead to excessive use of antireflux therapy and an escalation of interventions, including fundoplication, as symptoms may be attributed to gastroesophageal reflux disease. In addition, long-term untreated eosinophilic esophagitis may lead to recurrent strictures due to transmural esophageal inflammation, necessitating repeated dilatations. Eosinophilic esophagitis should be considered when children w...
Source: European Journal of Pediatric Surgery - August 24, 2015 Category: Surgery Authors: Krishnan, Usha Tags: Review Article Source Type: research

An Update on Diagnosis of Tracheomalacia in Children
Eur J Pediatr SurgDOI: 10.1055/s-0035-1559816Congenital tracheomalacia is the most common congenital tracheal abnormality and occurs in approximately 1:2,100 children. Tracheomalacia can be isolated or associated with other airway anomalies such as laryngomalacia, bronchomalacia, and large laryngeal clefts. Also, an abnormal division of the embryonic foregut is frequently associated with congenital tracheomalacia; mostly in the form of proximal esophageal atresia with distal tracheoesophageal fistula. In such cases, the ratio between the cartilage ring and the posterior membranous wall drops from the normal ratio of 4 to 5...
Source: European Journal of Pediatric Surgery - August 15, 2015 Category: Surgery Authors: Snijders, DeborahBarbato, Angelo Tags: Review Article Source Type: research

SNAPPE II Score As a Predictor of Survival in Neonates with Congenital Diaphragmatic Hernia: A Single Center Experience
Eur J Pediatr SurgDOI: 10.1055/s-0035-1554103 Introduction Prediction of mortality and morbidity in newborns with congenital diaphragmatic hernia (CDH) is too complex for practical use and may not be accurate. The main objective of this study was to evaluate the usefulness of the CDH Study Group equation and Score of Neonatal Acute Physiology Perinatal Extension (SNAPPE) II score to predict short-term outcomes of newborns with CDH. Materials and Methods Fifty-two neonates were admitted with CDH at Children's Hospital of Michigan from November 2001 to July 2009. Retrospective chart analysis was perform...
Source: European Journal of Pediatric Surgery - August 12, 2015 Category: Surgery Authors: Chiu, Louisa W.Desai, JagdishShanti, ChristinaRane, SharayuAgarwal, PrashantThomas, Ronald LeeKlein, MichaelChouthai, Nitin Shashikant Tags: Original Article Source Type: research

Central Vein Preservation in Critical Venous Access
Conclusion For children with critical venous access requirements, direct line exchange procedures are a robust and reproducible means of vein preservation. The outcomes compare favorably with those following the more traditional removal, a PF period and reinsertion.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - August 11, 2015 Category: Surgery Authors: Davidson, J.Paul, A.Patel, S.Davenport, M.Ade-Ajayi, N. Tags: Original Article Source Type: research

Laparoscopic Treatment of Intestinal Malrotation in Children
Eur J Pediatr SurgDOI: 10.1055/s-0035-1554914 Purpose Intestinal malrotation is a congenital intestinal rotation anomaly, which can be treated by either laparotomy or laparoscopy. Our hypothesis is that laparoscopic treatment leads to less small bowel obstruction because of the fewer adhesions in comparison to laparotomy, without increasing the risk of recurrent volvulus. We analyzed the outcome of patients who had a correction for intestinal malrotation after the introduction of laparoscopy. Methods All patients between 0 and 18 years who underwent a surgical procedure for malrotation in the Radboudu...
Source: European Journal of Pediatric Surgery - June 18, 2015 Category: Surgery Authors: Ooms, NinaMatthyssens, Lucas E. M.Draaisma, Jos MThde Blaauw, IvoWijnen, Marc H. W. A. Tags: Original Article Source Type: research

Esophageal Atresia: Improved Outcome in High-Risk Groups Revisited
Eur J Pediatr SurgDOI: 10.1055/s-0035-1551567 Objectives Improved survival in infants with esophageal atresia (EA) with a birth weight 
Source: European Journal of Pediatric Surgery - June 16, 2015 Category: Surgery Authors: Malakounides, GeorginaLyon, PaulCross, KatePierro, AgostinoDe Coppi, PaoloDrake, DavidKiely, EdwardSpitz, LewisCurry, Joe Tags: Original Article Source Type: research

The Surgical Management of H-Type Rectovestibular Fistula: A Novel Modification
Conclusion Our surgical management is a simple, safe, and probable choice for the treatment of H-type rectovestibular fistula with favorable outcomes.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 29, 2015 Category: Surgery Authors: Wu, Ye-mingWang, Cheng-dongLv, FanZhang, ChiYan, Zhi-long Tags: Original Article Source Type: research

Intramural Injection with Botulinum Toxin Type A in Piglet Esophagus. The Influencer on Maximum Load and Elongation: A Dose Response Study
Conclusions This study demonstrated that injection of 2 units/kg BTX-A into a nonanastomosed esophageal wall resulted in a modest increase in the maximum load achieved before bursting; this may be due to the muscle-relaxant effect of BTX-A. BTX-A injection produced no significant effects on elongation or esophageal histology. The clinical usefulness of BTX-A in treatment of OA is still unclear.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 29, 2015 Category: Surgery Authors: Ellebæk, Mark BremholmQvist, NielsSchrøder, Henrik DaaRasmussen, Lars Tags: Original Article Source Type: research

Y-Type Urethral Duplication: A True Variant of the Anomaly or a Misnomer?
Conclusion Several observations would support diagnosing the congenital connection between the urinary tract and the external anal orifice in the male as a congenital fistula rather than an accessory urethra. Confirming and accepting this information may have its impact on changing the current surgical approach.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 29, 2015 Category: Surgery Authors: AbouZeid, Amr A.Mohammad, Shaimaa A.Radwan, Nehal A.Safoury, Hesham S.El-Naggar, OsamaHay, Sameh A. Tags: Original Article Source Type: research

The Use of CT Scan in Hemodynamically Stable Children with Blunt Abdominal Trauma: Look before You Leap
Eur J Pediatr SurgDOI: 10.1055/s-0035-1554804We set out to determine the diagnostic value of computed tomographic (CT) scans in relation to the radiation dose, tumor incidence, and tumor mortality by radiation for hemodynamically stable pediatric patients with blunt abdominal injury. We focused on the changes in management because of new information obtained by CT. CT scans for suspected pediatric abdominal injury performed in our accident and emergency department were retrieved from the radiology registry and analyzed for: injury and hemodynamic parameters, changes in therapy, and radiological interventions. The dose leng...
Source: European Journal of Pediatric Surgery - May 27, 2015 Category: Surgery Authors: Nellensteijn, David R.Greuter, Marcel J.el Moumni, MoustafaHulscher, Jan B. Tags: Original Article Source Type: research

Quality of Life in Female Epispadias
Conclusion Patients with female epispadias have good long-term results regarding quality of life and sexuality, despite having some degree of urinary incontinence.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 27, 2015 Category: Surgery Authors: Morello, Virginia AmestyChocarro, GloriaLobato, RobertoMonsalve, ShirleyMartinez-Urrutia, Maria JoseLopez-Pereira, Pedro CarlosJaureguizar, Enrique Tags: Original Article Source Type: research

Epidural versus Patient-Controlled Analgesia after Pediatric Thoracotomy for Malignancy: A Preliminary Review
Conclusion Epidural catheter and PCA provided comparable pain relief and objective recovery course in children who underwent thoracotomy for oncologic disease; however, epidural catheter placement was associated with increased anesthesia charges, suggesting that PCA is a noninvasive, cost-effective alternative.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 27, 2015 Category: Surgery Authors: Gonzalez, Katherine W.Dalton, Brian G.Millspaugh, Daniel L.Thomas, Priscilla G.St Peter, Shawn David Tags: Original Article Source Type: research

Overall Quality of Life in Adult Biliary Atresia Survivors with or without Liver Transplantation: Results from a National Cohort
This study aims to compare HRQOL of transplanted and nontransplanted patients in a cohort of young adult BA survivors. Patients and Methods RAND-36 and Liver Disease Index Score (LDSI) questionnaires were sent to eligible adult patients with BA. Clinical characteristics were obtained from the NeSBAR (Netherlands Study group on Biliary Atresia Registry) and the national pediatric LT database. RAND-36 domain and summary scores were compared with those of an age-matched Dutch reference group. The correlations between several clinical variables and HRQOL were analyzed. Results Mean RAND-36 domain and summ...
Source: European Journal of Pediatric Surgery - May 27, 2015 Category: Surgery Authors: de Vries, WillemienLind, Robert C.Sze, Yuk-Kuengvan der Steeg, Alida F. W.Sieders, EgbertPorte, Robert JackVerkade, Henkjan J.Hulscher, Jan B. F.Hoekstra-Weeber, Josette E. H. M. Tags: Original Article Source Type: research

Modification of U-Stitch Laparoscopic Gastrostomy Technique to Minimize Suture Knot Abscess Formation
Conclusion Subcutaneous placement of stay suture within the open gastrostomy tract rather than within closed subcutaneous tissue may minimize suture knot abscess formation.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 26, 2015 Category: Surgery Authors: McCagg, JillianMarkham, SarahIdowu, OlajireNewton, ChristopherPalmer, BarnardKim, Sunghoon Tags: Original Article Source Type: research

Surgical Findings in Transfusion-Associated Necrotizing Enterocolitis
Conclusion No differences in surgical findings between TR48 and CN could be demonstrated in this investigation; therefore, the hypothesis that intestinal damage might be more severe in TNEC was not confirmed.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 26, 2015 Category: Surgery Authors: Couselo, MiguelFonseca, RosaMangas, LucíaVila, Juan José Tags: Original Article Source Type: research

Interleukin-23 Increases Intestinal Epithelial Cell Permeability In Vitro
Conclusion IL-23 in human breast milk is biologically active and negatively affects the barrier function of intestinal epithelial cells through the degradation of tight junction proteins.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 22, 2015 Category: Surgery Authors: Heinzerling, Nathan P.Donohoe, DeborahFredrich, KatherineGourlay, David M.Liedel, Jennifer L. Tags: Original Article Source Type: research

Does Severity of Pelvic Fractures Correlate with the Incidence of Associated Intra-Abdominal Injuries in Children?
Eur J Pediatr SurgDOI: 10.1055/s-0035-1551573 Background Pelvic fractures are considered a marker of injury severity, especially in the pediatric population. However, the correlation between the severity of pelvic fractures and incidence of associated abdominal injuries is not clear. Methods A retrospective cohort study involving blunt trauma patients up to the age of 14 years, who suffered from pelvic fractures, with or without associated intra-abdominal injuries. Results A total of 812 trauma patients were included in this study. Overall, 671 of them suffered from pelvic fractures with ab...
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Swaid, ForatPeleg, KobiAlfici, RicardoOlsha, OdedGivon, AdiKessel, Boris Tags: Original Article Source Type: research

Failure of First-Line Antibiotics in Nonoperative Management of Appendiceal Mass, toward a Second-Line Instead of Surgery?
Conclusions A gradual adapted antibiotherapy in nonoperative management of appendiceal abscess and mass is effective. We found no relevant predictive factor of failure of the first-line antibiotics.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Parmentier, BenoîtBerrebi, DominiquePeycelon, MatthieuDoit, CatherineGhoneimi, Alaa ElBonnard, Arnaud Tags: Original Article Source Type: research

Endoscopic Surveillance for Congenital Diaphragmatic Hernia: Unexpected Prevalence of Silent Esophagitis
Conclusion Even in the absence of symptoms, esophagitis revealed to have a high prevalence in CDH patients. A long-term clinical and instrumental follow-up is mandatory to early diagnose and treat GERD.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Morandi, AnnaMacchini, FrancescoZanini, AndreaPasqua, NoemiFarris, GiorgioCanazza, LorenaGentilino, ValerioDi Cesare, AntonioLeva, Ernesto Tags: Original Article Source Type: research

Vesicoscopic Treatment of Symptomatic Congenital Bladder Diverticula in Children: A 7-Year Experience
Conclusion Vesicoscopic diverticulectomy resulted a safe and effective procedure and can be considered a valid alternative to the open or laparoscopic procedures. In our opinion, routine use of vesicoscopy could become the gold standard for the treatment of CBD in children.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Marte, AntonioCavaiuolo, SilviaEsposito, MariaPintozzi, Lucia Tags: Original Article Source Type: research

Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Differentiated from Biliary Atresia
Conclusion Elevated total hexose in DBS measured by MS/MS associated with elevated amino acids, especially Cit can be used to diagnose NICCD and differentiate it from BA.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Gong, ZhenhuaXu, Wei-JueTian, Guo-LiZhang, TingLv, Zhibao Tags: Original Article Source Type: research

Surgical Success in Chronic Pancreatitis: Sequential Endoscopic Retrograde Cholangiopancreatography and Surgical Longitudinal Pancreatojejunostomy (Puestow Procedure)
In this study, eight (M:F ratio of 4:4) children underwent an LPJ and one female child had a more limited pancreatojejunostomy anastomosis following preliminary ERCP and stent placement where possible. Diagnoses included hereditary pancreatitis (n = 3), idiopathic or structural pancreatitis (n = 5), and duct stricture following radiotherapy (n = 1). Median duct diameter presurgery was 5 (4–11) mm. Endoscopic placement of a Zimmon pancreatic stent was possible in six with relief of symptoms in all. Median age at definitive surgery was 11 (range, 7–17) years with a median...
Source: European Journal of Pediatric Surgery - May 19, 2015 Category: Surgery Authors: Ford, KathrynPaul, AnuHarrison, PhillipDavenport, Mark Tags: Original Article Source Type: research

Ullrich–Turner Syndrome and Tumor Risk: Is There Another Chance to Early Gonadectomy in Positive TSPY and SRY Patients?
Eur J Pediatr SurgDOI: 10.1055/s-0035-1551568The presence of the Y chromosome in the karyotype of patients with disorders of sex differentiation is significantly associated with an increased risk to develop specific types of malignancies, predominantly type II germ cell tumors (GCTs). Gonadoblastoma in the gonads without an obvious testicular differentiation and intratubular germ cell neoplasia of unclassified type in testicular tissue are the precursor lesions of most GCTs. Gonadal dysgenesis, the characteristic feature of Ullrich–Turner syndrome (UTS), further contributes to increase this tumor risk. The reported i...
Source: European Journal of Pediatric Surgery - May 15, 2015 Category: Surgery Authors: Silveri, MassimilianoGrossi, ArmandoBassani, FrancescaOrazi, CinziaCamassei, Francesca DiomediZaccara, Antonio Tags: Original Article Source Type: research

Contrast Enema for Hirschsprung Disease Investigation: Diagnostic Accuracy and Validity for Subsequent Diagnostic and Surgical Planning
Conclusion We confirm that CE is a valuable tool for HD diagnosis; however, it should only be performed for subsequent diagnostic and surgical planning following histological confirmation of HD by RB. On the basis of this, an algorithm for an optimized investigation and management of HD is presented.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 24, 2015 Category: Surgery Authors: Frongia, GiovanniGünther, PatrickSchenk, Jens-PeterStrube, KaiKessler, MarkusMehrabi, ArianebRomero, Philipp Tags: Original Article Source Type: research

Prenatal and Postnatal Clinical Course of an Urachus Identified as an Allantoic Cyst in the Umbilical Cord
Conclusion The presence of an urachus identified as an allantoic cyst in the umbilical cord is frequently associated with spontaneous rupture during the prenatal period, resulting in a patent urachus after birth that requires surgical intervention.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 16, 2015 Category: Surgery Authors: Umeda, SatoshiUsui, NoriakiKanagawa, TakeshiYamamichi, TakuNara, KeigoUeno, TakehisaOwari, MitsuguUehara, ShuichiroOue, TakaharuKimura, TadashiOkuyama, Hiroomi Tags: Original Article Source Type: research

Extracorporeal Ureteric Stenting for Pediatric Laparoscopic Pyeloplasty
Conclusion Our data show that extracorporeal antegrade ureteric stent insertion is an easy-to-learn and a safe and reliable technique for pediatric dismembered pyeloplasty. It obviates the problem of having the stent in the pelvis during dissection and the need for patient repositioning.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 16, 2015 Category: Surgery Authors: Kocherov, StanislavLev, GenadyChertin, LeonidChertin, Boris Tags: Original Article Source Type: research

Foker Technique for the Management of Pure Esophageal Atresia: Long-Term Outcomes at a Single Institution
Conclusion FT was successful in achieving a primary anastomosis in 80% of the patients with LGEA, with a significant morbidity but favorable long-term outcomes.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 16, 2015 Category: Surgery Authors: Bobanga, Iuliana DitBarksdale, Edward Metz Tags: Original Article Source Type: research

Analysis of Sequelae after Pediatric Phalangeal Fractures
Conclusion Most sequelae of phalangeal fractures are consequences of fracture per se and are therefore fateful. However, the degree and severity of the long-term sequelae can be minimized by a correct and timely treatment.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 16, 2015 Category: Surgery Authors: Huelsemann, WiebkeSinger, GeorgMann, MaxWinkler, Frank J.Habenicht, Rolf Tags: Original Article Source Type: research

Perioperative Nutritional Management in Congenital Perineal and Vestibular Fistulas: A Systematic Review
Eur J Pediatr SurgDOI: 10.1055/s-0034-1544052 Background Surgical advancements have led to improved outcomes for children with congenital anorectal malformations with vestibular and perineal fistulas. However, the effect of perioperative nutritional management is debated and guidelines have not yet been established. Objective The study aims to give an overview of available published evidence, regarding the impact of different perioperative nutritional management protocols on surgical outcome. Methods A systematic literature review was conducted using PubMed, Embase, Cochrane Library, and CI...
Source: European Journal of Pediatric Surgery - February 5, 2015 Category: Surgery Authors: Hofmeester, Marrigje JosienDraaisma, Jos M. T. H.Versteegh, Hendt P.Huibregtse, Elizabeth C. P.van Rooij, Iris A. L. M.Blaauw, Ivo de Tags: Review Article Source Type: research

Improvements in Incontinence with Self-Management in Patients with Anorectal Malformations
Conclusion We suggest that colonic irrigation should be combined with self-management strategies in children with ARM. Adherence to therapy can be enhanced with the use of an individualized irrigation schedule. The amount of time required for the irrigation can be significantly reduced. Therefore, when establishing colonic irrigation in children and adolescents a focus should be placed on time-saving measures and self-regulation.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journa...
Source: European Journal of Pediatric Surgery - February 5, 2015 Category: Surgery Authors: Märzheuser, StefanieKarsten, KatharinaRothe, Karin Tags: Original Article Source Type: research

Evidence for Thoracoscopic Ligation of Patent Ductus Arteriosus
Eur J Pediatr SurgDOI: 10.1055/s-0034-1544051Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 5, 2015 Category: Surgery Authors: Gentilino, ValerioMacchini, FrancescoMorandi, AnnaLeva, Ernesto Tags: Letter to the Editor Source Type: research

Treatment of Idiopathic Achalasia in the Pediatric Population: A Systematic Review
Conclusion Adequate comparative data are lacking to determine the ideal treatment of pediatric achalasia. Appropriately designed randomized controlled trials with long-term follow-up are needed to determine ideal treatment algorithms in pediatric achalasia.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Sharp, Nicole E.St Peter, Shawn D. Tags: Review Article Source Type: research

Quality Measurement in Neonatal Surgical Disorders: Development of Clinical Indicators
Conclusion The development of quality indicators is an important step toward monitoring and, if necessary, improving the quality of neonatal surgical care. Internal or clinical indicators guarantee that the results are only disclosed to the participating center itself and are therefore no threat to individual doctors.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: van Heurn, Ernestde Blaauw, IvoHeij, HugoWijnen, MarcWijnen, ReneHulscher, Janvan der Zee, David Tags: Original Article Source Type: research

The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure
Eur J Pediatr SurgDOI: 10.1055/s-0034-1396417 Purpose Factors precipitating persistence of gastrocutaneous fistulas (GCFs) are not clearly understood. The role of proton pump inhibitors (PPIs) or histamine receptor antagonists in GCF closure is not yet studied. We aimed to identify whether these medications influence spontaneous GCF closure. Methods Retrospective review was performed on children who underwent gastrostomy tube insertion and removal from January 2010 to February 2013. Spontaneous GCF closure rates and medication use during gastrostomy tube removal were investigated. Results O...
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Thomas, Priscilla G.Sharp, Nicole E.Schnell, KatherineSnyder, Charles L.St Peter, Shawn D. Tags: Original Article Source Type: research

Spontaneous Intestinal Perforation and Necrotizing Enterocolitis: A 16-Year Retrospective Study from a Single Center
This study involved 3,464 preterm infants recruited over 16 years. A total of 136 NEC and 24 SIP were analyzed and adjusted odds ratios (aOR) were determined by logistic regression. Results Compared with the controls, NEC was associated with a Z-score for birth weight lower than –1 (aOR = 2.1 [1.1–3.9], p = 0.02) and lower than –2 (aOR = 4.4 [1.8–10.4], p 
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Suply, EtienneLeclair, Marc-DavidNeunlist, MichelRoze, Jean-ChristopheFlamant, Cyril Tags: Original Article Source Type: research

Serum Concentrations of Interleukin-6, Procalcitonin, and C-Reactive Protein: Discrimination of Septical Complications and Systemic Inflammatory Response Syndrome after Pediatric Surgery
Eur J Pediatr SurgDOI: 10.1055/s-0034-1544047 Background Early differentiation between sepsis and systemic inflammatory response syndrome (SIRS) is useful for therapeutic management in neonates and infants after surgery. Objective To compare the early (first 2 days) diagnostic value of interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) after surgery in the differentiation of subsequent SIRS and septic complications. Methods IL-6, PCT, and CRP were measured 0, 24, and 48 hours after surgery in neonates and infants with clinical suspicion of postoperative sepsis. Sensitiv...
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Neunhoeffer, FelixPlinke, SwantjeRenk, HannaHofbeck, MichaelFuchs, JörgKumpf, MatthiasZundel, SabineSeitz, Guido Tags: Original Article Source Type: research

Added Value of pH Multichannel Intraluminal Impedance in Adults Operated for Esophageal Atresia
Conclusion pH-MII adds further information when it comes to explaining what causes symptoms and esophageal histological changes in adults operated for EA.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Gatzinsky, VladimirAndersson, OlofEriksson, AndersJönsson, LinusAbrahamsson, KateSillén, Ulla Tags: Original Article Source Type: research

Impact of Epidural Failures on the Results of a Prospective, Randomized Trial
Conclusion In patients with failed epidural therapy, there is no significant difference in postoperative hospital course. Comparing those with well-functioning catheters to those in the PCA group, trial results are replicated—that is, no significant difference in length of stay, time to regular diet, or time to transition to oral medications. Therefore, failure rate in the EPI group did not influence the results of the trial.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: European Jour...
Source: European Journal of Pediatric Surgery - February 2, 2015 Category: Surgery Authors: Desai, AmitaAlemayehu, HannaWeesner, Kathryn A.St Peter, Shawn D. Tags: Original Article Source Type: research