The Role of PET-CT in differential diagnosis of malignant-paramalignant pleural effusion

We aimed to evaluate the diagnostic utility of PET-CT in differential diagnosis of MPE.Patients with pleural effusion and cancer who underwent PE T-CT were studied. Thoracentesis was performed for all cases.Sudy population consisted of 69 patients with a mean age of 63.55. Definitive diagnosis of MPE was confirmed by cytopathology In 16 cases, effusion was paramalignant. Malignant cells were detected in fluids with no FDG uptake in 13 lung cancer, 3 mesothelioma, 2 breast cancer, 2 colon cancer, 1 ovarian cancer, 1 gastric cancerand 1 endometrium cancer cases. The sensitivity of PET-CT in malignant pleural effusion is found to be 56.6%, specificity 50%, positive predictive value 78.9% and negative predictive value 25.8%. The efficacy of PET-CT in differential diagnosis of malignant-paramalignant pleural effusion is of limited value.Type of malignancyFluid proteinFluid albuminFluid LDHFluid glucoseFluid pHLDH ratioProtein ratioAlbumin gradiantSUVmax(mean)Lung42.255491127.361.880.651.181.25(0-9)Breast4.352.694131237.411.390.641.012.18 (0-4.8)Mesothelioma4.812.814201027.342.290.690.721.27 (0-3.1)Ovarian3.882.212671007.421.070.580.81.77 (0-2.5)Colon4.142.38835877.332.710.621.050Gastric4.562.52386967.671.910.651.041.23 (0-2)Bladder4.332.515221907.271.890.710.653.63 (1.8-5.8)Lymphoma2.921.134401247.470.780.452.011.25 (1-1.5)Cervix3.652.06887587.30.930.590.942Soft tissue5.083.08302867.371.800.730.920Ewing sarcoma4.022.682381027.561.170.61.322.8Uterus4.952.814311017.382.50.690.290Rec...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pleural and Mediastinal Malignancies Source Type: research