Sodium –glucose cotransporter inhibitors and oxidative stress: An update

In this report we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free radical generation or potentiation of cellular anti‐oxidative capacity, and its importance in preven tion of cardiovascular and diabetes complications. AbstractSodium –glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have antioxi dant properties that may be key to the reduction in cardiovascular death found in clinical trials. Oxidative stress is involved in the development and progression of atherosclerosis, as well as underlying diabetes complications, and may result from either increased free‐radical production, a reduc tion in antioxidative capacity, or a combination of both. In this report, we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free‐radical generation or potentiation of cellular antioxidative capacity, and its imp ortance in the prevention of cardiovascular and diabetes complications.

Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Alexandra E. Butler, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research