Histologic transformation of non-small-cell lung cancer in brain metastases

ConclusionsWe disclosed the histologic transformation of NSCLC in BM at a frequency not as low as expected, and speculated it as an evolution promoted by intratumor heterogeneity, though it warrants further prospective multi-institution investigations with comprehensive molecular analysis. Our findings provided further impetus for surgery when the metastatic or recurrent lesion is resectable, and repeated pathologic evaluation to help tailor individualized treatment.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research