Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease

Conclusions: An SEVR #x3c; 130% predicts fatal and non-fatal cardiovascular events in non-dialysis CKD patients.Cardiorenal Med 2019;9:41 –50
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 10 January 2019Source: Pharmacological ResearchAuthor(s): Raphael José Ferreira Felizardo, Ingrid Kazue Mizuno Watanabe, Patrizia Dardi, Luciana Venturini Rossoni, Niels Olsen Saraiva CâmaraAbstractThe bacteria community living in the gut maintains a symbiotic relationship with the host and its unbalance has been associated with progression of a wide range of intestinal and extra intestinal conditions. Hypertension and chronic kidney disease (CKD) are closely associated diseases with high incidence rates all over the world. Increasing data have supported the involvement of gu...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ABSTRACT Introduction: Endothelial dysfunction may contribute to hypercoagulable and inflammation states presents in renal transplant, chronic kidney disease (CKD) and its causes. These disorders can be evaluated by markers, such as thrombomodulin (TM), von Willebrand factor (vWF) and interleukin 6 (IL-6). Objectives: The aim of this study was to assess TM, vWF and IL-6 in renal transplant recipients (RTR) and associate their plasma levels with primary cause of end-stage renal disease (ESRD) and allograft function. Methods: 160 RTR were grouped according to the primary cause of CKD (G1: glomerulopathy; G2: hypertensive nep...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
Abstract Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy humans. Here, we measured plasma concentrations and urinary excretion of ADMA using GC-MS/MS in 130 living kidney donors before and at 1.6 (1.6-1.9) months after donation. We additionally analyzed 201 stable renal transplant recipients (RTR) that were included > 1 year aft...
Source: Amino Acids - Category: Biochemistry Authors: Tags: Amino Acids Source Type: research
Background A low diastolic blood pressure (DBP) is associated with increased cardiovascular events in patients with coronary artery disease or chronic kidney disease. Aim The aim of this study was to assess the association of blood pressure with cardiac events during the long-term follow-up of heart transplant recipients. Patients and methods In this prospective cohort study, we performed ambulatory blood pressure monitoring and home blood pressure monitoring in 76 transplant heart recipients 13.5±6.6 years after transplantation. The patients were followed for 54±17 months after blood pressure monitor...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Studies and Pathophysiology Source Type: research
Abstract In both women and men, chronic kidney disease (CKD) is associated with decreased fertility. Though a multitude of factors contribute to the reduction in fertility in this population, progressively impaired function of the hypothalamic-pituitary-gonadal axis appears to play a key role in the pathophysiology. There is limited research on strategies to manage infertility in the CKD population, but intensive hemodialysis, kidney transplantation, medication management and assisted reproductive technologies (ART) have all been proposed. Though fertility and reproductive care are reported as important elements o...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Abstract Chronic hepatitis C (CHC) is the most common cause of infection related deaths in USA according to Central Disease Control and Prevention (CDC) report in 2016. Hepatitis C is a blood borne virus and is common in chronic kidney disease (CKD) and in hemodialysis (HD) dependent patients. A majority of patients with CHC could remain asymptomatic and are still undiagnosed. Early detection of CHC and linkage of infected patients to care for evaluation and treatment is the standard of care as emphasized by Kidney Disease Improving Global Outcome (KDIGO) and American Association for the Study of Liver Disease- In...
Source: Seminars in Dialysis - Category: Urology & Nephrology Authors: Tags: Semin Dial Source Type: research
CONCLUSIONS: Our results suggested that alterations in the composition and function of gut microbiota are significantly correlated with the clinical conditions of in RT recipients, and future prospective studies of these correlations may provide evidence for predicting the clinical outcomes of RT recipients. PMID: 30613005 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Publication date: Available online 26 December 2018Source: Canadian Journal of CardiologyAuthor(s): Jan Benes, Martin Kotrc, Peter Wohlfahrt, Michael J. Conrad, Janka Franekova, Antonin Jabor, Petr Lupinek, Josef Kautzner, Vojtech Melenovsky, Petr JarolimAbstractBackgroundGrowth differentiation factor-15 (GDF-15) is a stress-inducible cytokine and member of the transforming growth factor-β cytokine superfamily that refines prognostic assessment in subgroups of patients with heart failure (HF). We evaluated its role in HF patients with chronic kidney disease (CKD, eGFR
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Novel oral anticoagulants are often used in patients with chronic kidney disease and atrial fibrillation, but what do we know about the benefits and risks of these agents in this population?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
Purpose of review Consistent associations between variants of the apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy have been reported in individuals of African descent. Donor APOL1 genotype has also been linked to shorter renal allograft survival. This review summarizes recent advances in understanding the biology of APOL1 and their implications to kidney donors and recipients. Recent findings Approximately 12–13% of African Americans have two renal risk APOL1 variants but most do not develop kidney disease. Although the exact mechanisms linking APOL1 genotype to renal injury are not known, evidence fr...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: RENAL TRANSPLANT: Edited by Yasir A. Qazi Source Type: research
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