A systematic review of single-dose aminoglycoside therapy for urinary tract infection: Is it time to resurrect an old strategy?

The objective of this study was to investigate whether a single aminoglycoside dose adequately treated UTI.Methods: A systematic search of PubMed/MEDLINE and Google Scholar databases was performed through September 2018 for English-language original research articles assessing the efficacy of one-time parenteral aminoglycoside as UTI monotherapy.Results: Of 252 potentially relevant studies, 13 met inclusion criteria, representing 13,804 patients. Patient age ranged from 2 weeks to>70 years; both inpatient and outpatient settings were represented. Cystitis was more common than pyelonephritis and more females were represented than males. Escherichia coli was the most commonly isolated uropathogen. The pooled microbiologic cure rate with single-dose aminoglycoside therapy was 94.5% +/- 4.3%. Cure was sustained (no recurrence) for 73.4% +/- 9.6% of patients at day 30. Lower cure rates were observed among patients with radiographic urinary tract abnormality (Chi-square P
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research

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This study was aimed to estimate the length of the MIC in the interforaminal safe zone, to analyse its course in relation to the lingual and the buccal cortical plates of the mandible using cone beam computed tomography (CBCT) scans and to relate the above findings to age, gender, dental status and Malaysian races.MethodsRetrospective analysis of 100 CBCT scans (n = 200) was performed on both sides of the mandible. Cross-sectional and panoramic images were reconstructed. The length of the MIC and the horizontal distances between the MIC and the buccal and the lingual cortical plates were measured at the three...
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Authors: Altaner C, Altanerova U, Jakubechova J PMID: 31608134 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Bader MS, Loeb M, Leto D, Brooks AA Abstract Urinary tract infections (UTIs) caused by antibiotic- resistant Gram-negative bacteria are a growing concern due to limited treatment options. Knowledge of the common uropathogens in addition to local susceptibility patterns is essential in determining appropriate empiric antibiotic therapy of UTIs. The recommended first-line empiric antibiotic therapy for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantion, a 3-g single dose of fosfomycin tromethamine, or a 5-day course of pevmecillinam. High...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Publication date: Available online 14 October 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): E.F. Matthews, K.M. Abrams, S.J.B. Cooper, J.A. Huey, M.J. Hillyer, W.F. Humphreys, A.D. Austin, M.T. GuzikAbstractLike other crustacean families, the Parabathynellidae is a poorly studied subterranean and aquatic (stygobiontic) group in Australia, with many regions of available habitat having not yet been surveyed. Here we used a combined approach of molecular species delimitation methods, applied to mitochondrial and nuclear genetic data, to identify putative new species from material obtained from remote subterranea...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): Mohammad Asad, Muhammad Nadeem Arshad, Salman A. Khan, Mohammad Oves, Muhammad Khalid, Abdullah M. Asiri, Ataualpa A.C. BragaAbstractThe chalcones have been cyclized into the N-propionyl-2-pyrazolines using propionic acid with hydrazine hydrate. The structures of pyrazolines were determined by FT-IR, NMR spectroscopy, and confirmed by single crystal X-ray diffraction (SC-XRD) study. Further, a combined experimental and density functional theory (DFT) based study of these pyrazolines has been reported. A comprehensive DFT investig...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 14 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xianhu Wei, Qingping Wu, Ying Feng, Minling Chen, Shuhong Zhang, Moutong Chen, Jumei Zhang, Guangzhu Yang, Yu Ding, Xiaojuan Yang, Qinghua Ye, Youxiong Zhang, Qihui Gu, Juan Wang, Shi Wu, Rui Pang, Ying LiAbstractDetection and isolation of both O157:H7 and non-O157:H7 Escherichia coli are essential for the evaluation and surveillance of the associated foodborne disease risk. However, the development of a chromogenic/fluorogenic culture medium for detection and isolation is challenging yet urgent. β-Glucuronidase (GUS)...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
ConclusionsPrevious history of UTI, antibiotic treatment, or hospitalization within previous 3  months and underlying disease are risk factors for ESBL UTI in children under 24 months of age. However, relapse rate was
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions: Given the fact that the percentage of erupted third molars by age 18 was found to be <50% on an average in this Ugandan population, we should reconsider the use of third molar eruption as a definitive tool for age estimation in this population.
Source: Journal of Forensic Dental Sciences - Category: Dentistry Authors: Source Type: research
Conclusion: The findings of the present study reveal that overweight influences early eruption of the mandibular third molar tooth, although there is no trend between socioeconomic status and the age of eruption of the mandibular third molar.
Source: Journal of Forensic Dental Sciences - Category: Dentistry Authors: Source Type: research
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
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