Sleeping beauty helps identify genes involved in a fatty liver-associated liver cancer

(Osaka University) Hepatocellular carcinoma, a deadly form of liver cancer, is increasingly being linked to non-alcoholic fatty liver disease; however, the underlying genetic mechanism of disease progression had remained unknown. Using a Sleeping Beauty mutagenesis screen, Osaka University researchers found that Sav1 and downstream components of the Hippo signaling pathway are drivers of the development of liver cancer associated with fatty liver disease. These findings pave the way for liver cancer treatments targeting the Hippo pathway.

Source: EurekAlert! - Cancer - October 17, 2018 Category: Cancer & Oncology Source Type: news