Distinct roles of angiotensin receptors in autonomic dysreflexia following high-level spinal cord injury in mice.

In conclusion, we identified a specific role of the Ang-(1-7) receptor Mas in regulating the systemic blood pressure increase in AD in T4-SCI mice. Furthermore, AT1a signaling is not involved in this hemodynamic response, but underlies increased vascular reactivity in mesenteric arteries in response to Ang II, where it may contribute to adaptive changes in regional blood flow.
PMID: 30315807 [PubMed - as supplied by publisher]

Source: Experimental Neurology - October 10, 2018 Category: Neurology Authors: Järve A, Todiras M, Lian X, Filippelli-Silva R, Qadri F, Martin RP, Gollasch M, Bader M Tags: Exp Neurol Source Type: research