Nanomedicine for gene delivery for the treatment of cardiovascular diseases.

Nanomedicine for gene delivery for the treatment of cardiovascular diseases. Curr Gene Ther. 2018 Oct 03;: Authors: Yan C, Quan XJ, Feng YM Abstract Myocardial infarction (MI) is the most severe ischemic heart disease and directly leads to heart failure till death. Target molecules have been identified in the event of MI including increasing angiogenesis, promoting cardiomyocyte survival, improving heart function and restraining inflammation and myocyte activation and subsequent fibrosis. All of which are substantial in cardiomyocyte protection and preservation of cardiac function. To modulate target molecule expression, virus and non-virus-mediated gene transfer have been investigated. Despite successful in animal models of MI, virus-mediated gene transfer is hampered by poor targeting efficiency, low packaging capacity for large DNA sequences, immunogenicity induced by virus and random integration into human genome. Nanoparticles could be synthesized and equipped on purpose for large scale production. They are relatively small in size and do not incorporate into genome. They could carry DNA and drug within the same transfer. All of these properties make them an alternative strategy for gene transfer. In the review, we first introduce the pathological progression of MI. After concise discussion the current status of virus-mediated gene therapy in treating MI, we overview the history and development of nanoparticle-based gene deliver...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research