Epigenetic alterations caused by aflatoxin b1: a public health risk in the induction of hepatocellular carcinoma

Aflatoxin B1 (AFB1) is currently the most commonly studied mycotoxin due to its great toxicity, its distribution in a wide variety of foods such as grains and cereals and its involvement in the development of  + (HCC). HCC is one of the main types of liver cancer, and has become a serious public health problem, due to its high incidence mainly in Southeast Asia and Africa. Studies show that AFB1 acts in synergy with other risk factors such as hepatitis B and C virus (HBV and HCV) leading to the devel opment of HCC through genetic and epigenetic modifications.

Source: Translational Research - September 14, 2018 Category: Research Authors: Roseane Guimar ães Ferreira, Magda Vieira Cardoso, Karine Maria de Souza Furtado, Kaio Murilo Monteiro Espíndola, Ruanderson Pereira Amorim, Marta Chagas Monteiro Source Type: research