Asthma COPD overlap: Impact of associated comorbidities
The objective of this review is to describe current knowledge and clinical implications of the overlapping features of asthma and COPD, and discuss the prevalence and impact of comorbidities, such as osteoporosis, cardiovascular disease, gastroesophageal reflux disease, and depression, in this subgroup of patients.
ConclusionsThe findings highlight the acceptability of physical activity as a mental health intervention tool within a post-secondary context. Importantly the results provide implications for developing strategies to incorporate physical activity as an acceptable support method within mental health services.
The U.S. Department of Veterans Affairs (VA) has set up a new institute, the...Read more on AuntMinnie.comRelated Reading: VA: Delay in patient diagnosis leads to suicide VA identifies radiology reporting delays at Kan. hospital Did VA hospitals cancel valid radiology orders to clear backlog? VA radiologist wins White House fellowship Veterans get inappropriate prostate imaging outside VA
Condition: Asthma Interventions: Drug: Flamboyant 200/12; Drug: Budesonide / Formoterol 400/12; Other: Flamboyant 200/12 Placebo; Other: Budesonide / Formoterol 400/12 Placebo Sponsor: EMS Not yet recruiting
Condition: Asthma Interventions: Drug: Flamboyant 125/12; Drug: Budesonide/formoterol 200/6; Other: Flamboyant 125/12 Placebo; Other: Budesonide/formoterol 200/6 placebo Sponsor: EMS Not yet recruiting
Conditions: Self-Harm; Depression Intervention: Other: COPESS Sponsors: Liverpool John Moores University; University of Liverpool; University of Manchester; University of Leeds Not yet recruiting
Conditions: COPD; Chronic Respiratory Insufficiency Intervention: Device: Free 02 Sponsor: ADIR Association Not yet recruiting
Funding Opportunity PAR-20-072 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites submission of investigator-initiated Program Project (P01) applications. The proposed programs may address scientific areas relevant to the NIAID mission including the biology, pathogenesis, and host response to microbes, including HIV; the mechanisms of normal immune function system development and function; and immune dysfunction resulting in autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics t...
Publication date: Available online 9 December 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jörg Kleine-Tebbe, Claudia Mailänder
CONCLUSION: These results indicate that FLJC may significantly attenuate oxidative damage of osteoblasts induced by H2O2 via the Nrf2/HO-1 signaling pathway, providing new insights to guide development of treatments for osteoporosis induced by oxidative injury. PMID: 31810119 [PubMed - in process]
Publication date: Available online 8 December 2019Source: The Lancet PsychiatryAuthor(s): Senthil Amudhan, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, Girish Nagaraja Rao, David Vincent Sheehan, Arun Mahadeo Kokane, Bir Singh Chavan, Pronob Kumar Dalal, Daya Ram, Kangkan Pathak, Raj Kumar Lenin Singh, Lokesh Kumar Singh, Pradeep Sharma, Pradeep Kumar Saha, Chellamuthu Ramasubramanian, Ritambhara Yeshwant Mehta, Theerthankara Meethal ShibukumarSummaryBackgroundIndia accounts for 18% of the global population and 26·6% of global suicide deaths. However, robust population-based, nationally representative data ...