Long non-coding RNA HOTAIR promotes the self-renewal of leukemia stem cell through epigenetic silencing of p15

Acute myeloid leukemia (AML) is characterized by the blockage of differentiation and uncontrolled proliferation. Although conventional chemotherapy and stem cell transplantation markedly improve the overall survival in AML patients, half adult patients and above 80% older patients (>60 years) are fatal due to primary refractoriness, relapse, or treatment-related mortality [1]. Various genetic mutations, such as c-Kit, FLT3, and WT1, lead to the initiation and development of AML [2]. However, increasing studies have demonstrated that epigenetic modulations, such as non-coding RNAs including microRNAs and long non-coding RNAs, play an important role in the pathogenesis of AML.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research