Study: Chemicals in some vegetables prevent cancer in mice

Chemicals in some vegetables, including kale, cabbage and broccoli, helped prevent colon cancer in mice, according to a study.
Source: Health News - - Category: Consumer Health News Source Type: news

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ConclusionsThe study highlights increasing incidence of colon cancer in younger subjects and a decrease in incidence rates for rectal cancer in females.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Authors: Zhang H, Song Y, Yang C, Wu X Abstract Colorectal cancer (CRC) is a highly heterogeneous disease worldwide. Long non‑coding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) plays a crucial role in the development of several cancers. However, the role of TUSC7 in the tumorigenesis of CRC has not been explored. The TUSC7‑overexpressing CRC cell lines SW480 and CaCo‑2 were generated to investigate the effects of TUSC7 on the growth, migration, invasion and epithelial‑mesenchymal transition (EMT) of CRC cells. CCK‑8, wound‑healing and Transwell assays were used to evaluate CRC cell proliferation, ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
This study reports the synthesis and production of a relatively robust dual drug-loaded liposomal formulation by modified thin film hydration method which substantially entraps both the drugs. Even though there have been reports of the combinatorial regimen involving apigenin and 5-Flurouracil our study reports the optimal molar ratio for effective synergistic therapeutic application of this drug combination to alleviate colorectal cancer. The cytotoxicity and cellular effects of individual, combinatorial free drugs and their liposomal counterparts tested against two human colon cancer cell lines revealed significantly hig...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 April 2019Source: Nitric OxideAuthor(s): Hugo P. Monteiro, Elaine G. Rodrigues, Adriana K.C. Amorim Reis, Luiz S. Longo, Fernando T. Ogata, Ana I.S. Moretti, Paulo E. da Costa, Ana C.S. Teodoro, Maytê S. Toledo, Arnold SternAbstractCancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammator...
Source: Nitric Oxide - Category: Chemistry Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Authors: Rezasoltani S, Dabiri H, Asadzadeh-Aghdaei H, Sepahi AA, Modarressi MH, Nazemalhosseini-Mojarad E Abstract Gut microbiota is the complex community of microorganisms that live in the digestive tracts of humans and other animals, including insects. The relationship between gut microbiota and human health is mutualistic and altered bacterial compositions in fecal and mucosal specimens of colon in patients with cancer compared to healthy subjects were observed. Thereby, studying the gut microbiota, their interactions with the host and their alterations in colorectal cancer (CRC) patients could be helpful to di...
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
ICD is a prerequisite for induction of patient-specific protective immunity against tumor antigens. We hypothesize that the efficacy of Extracorporeal photochemotherapy (ECP) in initiating anti-lymphoma tumor specific immunity is traceable to its efficient induction of ICD in cutaneous T cell lymphoma (CTCL) malignant cells following their lethal exposure to photoactivated 8-methoxysporalen (8-MOPA). We tested that premise in a standard animal ICD vaccination assay, in three murine solid tumor models (sB16-OVA melanoma, YUMMER melanoma and MC38 colon cancer).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Photobiology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31002181 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer, Published online: 19 April 2019; doi:10.1038/s41416-019-0442-5LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Authors: Kim SE, Lee SJ, Cha JY, Yi SW, Kim TS, Cho IL, Kwak JY, Oh KH Abstract Colon cancer is very rarely accompanied by tumor thrombosis of the superior mesenteric vein (SMV). A 46-year-old patient had been diagnosed with SMV tumor thrombosis related to colon cancer without hepatic metastasis and underwent right hemicolectomy with SMV tumor thrombectomy. Tumor thrombosis was pathologically confirmed as metastatic colon cancer. There has been no recurrence for 12 months with 12 cycles of adjuvant-chemotherapy. PMID: 30992420 [PubMed - as supplied by publisher]
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
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