Study: Chemicals in some vegetables prevent cancer in mice

Chemicals in some vegetables, including kale, cabbage and broccoli, helped prevent colon cancer in mice, according to a study.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Suppression of glycolysis by 2 ‐deoxy‐D‐glucose (2‐DG) stimulates apoptosis in SK‐N‐BE(2), but attenuates in HCT116 cells. In both cell lines 2‐DG stimulates stress of endoplasmic reticulum (ER), which ends up in apoptosis in SK‐N‐BE(2) but in autophagy in HCT116 cells. Prevention of ER stress by mannose attenua tes apoptosis in SK‐N‐BE(2) cells, and reverses suppression of apoptosis in HCT116 cells. The dependence of tumors on glycolysis for ATP generation offers a rationale for therapeutic strategies aimed at selective inhibition of the glycolytic pathway. Analysis of tumor cell responses to antican...
Source: FEBS Journal - Category: Research Authors: Tags: Original Article Source Type: research
Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target. Oncol Rep. 2018 Nov 15;: Authors: Horibe T, Torisawa A, Masuda Y, Kawakami K Abstract P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal and cancer cell lines by flow cytometry using an affinity‑purified anti‑P5 antibody ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 15 November 2018Source: Saudi Journal of Biological SciencesAuthor(s): Yong Cao, Fei Dai, Yanmei Li, Lu Jia, Yunpeng Luan, Youjie ZhaoAbstractThe roots of Codonopis bulleynana Forest ex diels (cbFed), locally known as Tsoong, have been used as a tonic food. Tsoong has wide range of pharmacological effects, including anticancer effects. In the present study, the anticancer activity of Tsoong and its potential molecular mechanisms were investigated. Using high throughput sequencing the apoptotic pathway was ranked as one of the most important pathways and the differential expressions of apo...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
In conclusion, these findings suggested that P4HB knockdown may induce HT29 human colon cancer cell apoptosis through the generation of ROS and inactivation of the STAT3 signaling pathway. PMID: 30431122 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In this study, we report a simple process for the preparation of NiO-NPs. X-ray diffraction and transmission electron microscopy were used to characterize the surface architecture and dimension of the synthesized NiO-NPs. The average diameter of the NiO-NPs was approximately 20–25 nm. We used two human colon cancer cell lines, HT-29 and SW620, to assess the nanoparticles’ cytotoxicity. The MTT assay showed that the NiO-NPs reduced cell viability of HT-29 and SW620 cell lines. The results of inverted microscopy showed the highest cytotoxic activity with 600 μg/ml concentration of NiO-NPs on HT-2...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
ConclusionsObesity is positively associated with CC but not RC, and abdominal obesity exerts an independent effect. Reproductive factors had at best a weak effect on CC and RC.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract Redox-active compounds such as copper-phenanthroline are known as artificial/chemical nucleases with a great impact and potential for their applications as metallotherapeutics. In that vein, the mononuclear copper(II) complexes [Cu(L)2(bipy)] (1), [Cu(L)2(bipy)(H2O)] (2) and [Cu(L)2(phen)(H2O)] (3), where L = 2-thiophene carboxylate, bipy = 2,2΄-bipyridine and phen = 1,10-phenanthroline, have been prepared and pharmacochemically studied, while the crystal structure of 1 is also reported. All the tested complexes preferably bind to CT-DNA via minor groove as resulted from UV spectroscopy studi...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
AbstractColorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Accumulating evidence has suggested that probiotics affect cellular pathways and specific genes involved in slow growth. Probiotics reduce the impact or stop the growth of cancer cells and tumors in animal models and human cell lines. The aim of this study was to investigate the effect ofSaccharomyces cerevisiae (S. cerevisiae) on cell growth, metastasis, and apoptosis of the HT-29 colon cancer cell line. The HT-29 cells andS.cerevisiae were co-cultured in order to study the effects ofS.cerevisiae on cell apoptosis, growth, and ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
The histone transmethylase complex comprising WD repeat domain 77 (WDR77) and protein arginine methyltransferase 5 (PRMT5) catalyzes dimethylation of H4R3 (H4R3me2) and drives cancer cell proliferation and migration, but its regulation is not fully understood. Here, we report that sirtuin 7 (SIRT7) directly deacetylates WDR77 and that this deacetylation interferes with the WDR77–PRMT5 interaction and suppresses proliferation of human colon cancer HCT116 cells. Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77'...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
In this study, immunohistochemistry was performed to examine the expression of GARP and Foxp3 in 19 human PTC tissues (including 10 cases with and 9 cases without lymph node metastasis) and 20 benign thyroid diseases (including 10 cases with nodular goiter and 10 cases with adenoma). Compared with benign thyroid diseases, we found a significant increase in the expression of GARP in PTC. Increased GARP expression in PTC was positively correlated with increased expression of Foxp3, which is very important for development of Tregs. But, there is no significant association of elevated expression of GARP with lymph node metasta...
Source: Endocrine Pathology - Category: Pathology Source Type: research
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