38. The role of CYP2D6 Single Nucleotide Polymorphism (SNP) for the prediction and treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Chemotherapy-induced peripheral neuropathy (CIPN) and neurologic pain in cancer patients are manifestations that impact patient quality of life both during and after treatment. Management of CIPN and pain requires pharmacogenetic knowledge of genes such as CYP2D6 that play a major role in drug metabolism. CYP2D6 ’s varying levels of drug metabolic activity have been correlated with specific functional polymorphisms. In this pilot study, a novel multiplex single-nucleotide polymorphism (SNP) extension panel analyzing SNPs within CYP2D6 was evaluated for clinical relevance in identifying patients at risk fo r developing CIPN as well as assessing efficacy for patients receiving treatment to manage cancer-related pain.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research