Microvascular endothelial dysfunction during cardiopulmonary bypass in surgery for correction of cyanotic and acyanotic congenital heart disease

ConclusionThe evaluation of systemic microvascular reactivity on the forehead skin of infants and children using LDPM appears to be a valuable tool for optimizing microvascular perfusion during CPB in pediatric cardiac surgery.Graphical abstractBaseline values (BL) of skin microvascular flow and skin microvascular vasodilator responses induced by local thermal hyperemia (TH), expressed as cutaneous vascular conductance [arbitrary perfusion units (APU)/mean arterial pressure, in APU/mmHg] after the induction of general anesthesia (postinduction, PI), 20 min after the beginning of cardiopulmonary bypass (CPB) and 20 min after the discontinuation of CPB (final, F) in acyanotic (AC) and cyanotic (C) patients.**P < 0.01; ****P < 0.0001 compared with BL values.#P < 0.05, ####P < 0.0001 compared with TH-PI and TH-F.&&P < 0.001 compared with BL-PI and BL-CPB.
Source: Microvascular Research - Category: Biochemistry Source Type: research