Advances in the diagnosis and management of cardiomyopathy in duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a systemic X-linked disorder with an incidence of 10.7 to 27.8 per 100,000 [1]. The disease results from a mutation in the gene for the dystrophin protein resulting in progressive muscle necrosis, apoptosis and fibrosis. Muscle cell destruction directly affects many organ systems resulting in loss of ambulation, respiratory failure, heart failure and premature death [2,3]. With improvements in respiratory management, cardiac disease has emerged as a major cause of morbidity and mortality rendering the cardiologist an essential member of the multidisciplinary DMD care team [4].

Source: Neuromuscular Disorders - July 5, 2018 Category: Neurology Authors: Kan N. Hor, May Ling Mah, Pace Johnston, Timothy P. Cripe, Linda H. Cripe Tags: Review Source Type: research