Ferulic Acid May Target MyD88-Mediated Pro-Inflammatory Signaling – Implications for the Health Protection Afforded by Whole Grains, Anthocyanins, and Coffee

Higher dietary intakes of anthocyanins have been linked epidemiologically to decreased risk for metabolic syndrome, type 2 diabetes and cardiovascular events; clinical trials and rodent studies evaluating ingestion of anthocyanin-rich extracts confirm favorable effects of these agents on endothelial function and metabolic syndrome. However, these benefits of anthocyanins are lost in rats whose gut microbiome has been eliminated with antibiotic treatment – pointing to bacterial metabolites of anthocyanins as the likely protective agents.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research