Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b–4 stages chronic кidney disease patients: a randomized pilot study

ConclusionLPD  + KA provides support for nutrition status and contributes to more efficient correction of FGF-23 and Klotho abnormalities that may result in cardiovascular calcification and cardiac remodeling decreasing in CKD. At the same time, a prolonged LPD alone may lead to malnutrition.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research

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This study aims to analyse the prevalence and progression of subclinical atherosclerosis in CKD patients with and without diabetes.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Authors: Vallianou NG, Mitesh S, Gkogkou A, Geladari E Abstract Chronic Kidney Disease is a growing health burden world widely. Traditional and mutual risk factors between CVD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, family history and male gender. In this review, we will focus on whether or not early CKD is an important risk factor for the presence, severity and progression of CVD. Specifically, we will examine both traditional and novel risk factors of both CKD and CVD and how they relate to each other. We will also assess if early treatment of CKD, intensive compared to standa...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Conclusions: CD146 is associated with kidney injury and could be a good marker to predict renal outcomes in patients with early stages of DN.Cell Physiol Biochem 2018;48:63 –74
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
ConclusionsAt early follow-up, high-risk subgroups had lower ICERs than the overall cohort when CABG was compared with PCI. A personalised, multidisciplinary approach to treatment of patients may enhance cost containment, as well as improving clinical outcomes following revascularisation strategies.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Abstract Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research
Publication date: Available online 15 June 2018Source: American Journal of Kidney DiseasesAuthor(s): Tamara Glavinovic, Thomas Ferguson, Paul Komenda, Claudio Rigatto, Todd A. Duhamel, Navdeep Tangri, Clara BohmRationale &ObjectiveSedentary behavior and low physical activity are associated with incident diabetes, cardiovascular disease, and early mortality. Previous studies have examined associations between chronic kidney disease (CKD) and physical activity, but little is known about the role of sedentary time.Study DesignCross-sectional national survey.Setting &ParticipantsA nationally representative sample of ad...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Richard J. Johnson, George L. Bakris, Claudio Borghi, Michel B. Chonchol, David Feldman, Miguel A. Lanaspa, Tony R. Merriman, Orson W. Moe, David B. Mount, Laura Gabriella Sanchez Lozada, Eli Stahl, Daniel E. Weiner, Glenn M. ChertowUrate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome, but its relationship to kidney disease, cardiovascular disease, and diabetes remains controversial. A scientific workshop organized by the National Kidney Foundation was held in September 2016 to review c...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Digsu N. Koye, Dianna J. Magliano, Christopher M. Reid, Christopher Jepson, Harold I. Feldman, William H. Herman, Jonathan E. ShawBackgroundReduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown.Study DesignMulticenter prospective cohort study.Setting &ParticipantsWe included 1,908 participants with diabetes and reduced GFR enro...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionMitochondrial DNA is readily detectable in the urinary supernatant of non-diabetic CKD, and its level correlates with the rate of renal function decline and predicts the risk of doubling of serum creatinine or need of dialysis. Further studies are needed to determine the value of urinary supernatant mtDNA level as a prognostic indicator of non-diabetic CKD
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: June 2018Source: The Journal of Steroid Biochemistry and Molecular Biology, Volume 180Author(s): Vivek Kumar, Ashok Kumar Yadav, Manphool Singhal, Vinod Kumar, Anupam Lal, Debasish Banerjee, Krishan Lal Gupta, Vivekanand JhaAbstractVitamin D deficiency is common and associated with mortality in chronic kidney disease (CKD) patients. Cardiovascular disease (CVD) is the commonest cause of mortality in CKD patients. In a randomized, double blind, placebo controlled trial, we have recently reported favorable effects of vitamin D supplementation on vascular &endothelial function and inflammatory biomarkers...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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