Positive Effects of Bisphosphonates on Osteogenic Differentiation in Patient-Derived Mesenchymal Stem Cells for the Treatment of Osteoporosis

CONCLUSION:Our study using a clinically relevantin vitro model suggests that bisphosphonate treatment is more effective for patients with osteoporosis than its preventive effect for healthy person. In addition, patient-specific responses to bisphosphonates should be considered rather than bisphosphonate type prior to prescription. Further investigations are needed to determine how bisphosphonates influence hBMSCs function to mediate bone quality and turnover in osteoporotic patients. Such studies can generate novel approaches to treat age-related osteoporotic bone loss.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research

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ConclusionsTwo checklists and a list of situations to avoid were generated to facilitate the management of comorbidities in AxSpA. In a future step, their utility and acceptance will be tested by a broad group of users that includes doctors, patients and nurses.ResumenObjetivosIdentificar las comorbilidades prioritarias en la espondiloartritis axial (EspAx) y recomendar cómo hacer su seguimiento desde una perspectiva eminentemente práctica.MétodosSe seleccionó a un grupo multidisciplinar (10 reumatólogos [6 expertos en EspAx], 2 médicos de familia, una internista, una cardió...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Authors: Weng F, Wang J, Yang L, Zeng J, Chu Y, Tian Z Abstract Clinical value of expansive pedicle screw in lumbar short-segment fixation and fusion for patients with osteoporosis was investigated. A total of 80 patients with lumbar compression fracture but without obvious nerve compression were selected and divided into the observation group (n=40) and the control group (n=40) using a random number table. The observation group used the expansive pedicle screw, and the control group received conventional pedicle screw fixation and bone graft fusion. In the observation group, the operation and hospitalization time ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Li S, Jiang H, Gu X Abstract Glucocorticoids (GCs) are widely used to treat chronic diseases. Prolonged and/or overdose administration of GCs has many side-effects to human health including GC-induced osteoporosis (GIOP). In this investigation, the objective was to assess the influence that echinacoside (ECH) exerts upon dexamethasone-treated murine osteoblastic MC3T3-E1 cells. We found that ECH (5, 10, 20 and 40 mg/l) inhibited dexamethasone (1,000 nM)-suppressed cell viability as demonstrated by Cell Counting Kit-8 (CCK-8) assay. The dose of 10 mg/l was selected for the following experiments because this...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusions There is a high prevalence of fat-soluble vitamin deficiencies, osteopathy, and malnutrition in CP patients, which is underestimated due to a lack of effective diagnosis and suboptimal therapies for EPI.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
ConclusionWe anticipated that E. longifolia that enhances bone regeneration on the one hand and suppresses osteoclast’s maturation on the other hand may have great therapeutic value in treating osteoporosis and other bone-erosive diseases such as rheumatoid arthritis and metastasis associated with bone loss.
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
The objective of this study was to assess the effect of a modified human-like collagen calcium complex on osteoporosis mice. BHK (Baby Hamster Kidney) cells were used to compare the cytotoxicity of different calcium reagents with the MTT test. Six-week-old male mice (n = 80) were randomly divided into eight groups: a blank group (blank), control group (control), human-like collagen calcium group (HLC-Ca), thiolated human-like collagen calcium group (SH-HLC-Ca), phosphorylated human-like collagen calcium group (Pi-HLC-Ca), gluconate group (Glc-Ca), calcium carbonate group (CaCO3) and D-cal group (B). A systematic analys...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
AbstractPurpose of ReviewHomocystinuria is a congenital metabolic disorder in which cystathionine β-synthase deficiency results in a prominent increase in homocysteine (serum levels>  100 μM), causing mental retardation, atherosclerotic cerebral infarction, and osteoporosis accompanied by fragility fractures. Encountering a case with excessive homocysteinemia such as that seen in hereditary homocystinuria is unlikely during usual medical examinations. However, in individuals who have vitamin B or folate deficiency, serum homocysteine concentrations are known to increase. These individuals may also ha...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Experimental Dermatology,Volume 0, Issue ja, -Not available-.
Source: Experimental Dermatology - Category: Dermatology Authors: Source Type: research
AbstractPrevious studies on the association between social support and bone health outcomes did not produce consistent results. The main goal of this study was to resolve the inconsistency by systematically examining the studies on the association in the last two decades. In order to do that, we distinguished between two types of social supports: structural supports, which is the pattern of person ’s social relationship, and functional support, which is the perceived specific functions from social ties. For fracture, structural social support, especially marital (or cohabitation) status, showed a strong association b...
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research
CONCLUSIONS: Within the limits of this systematic review, implant treatment concepts seem to be a valuable approach in patients with radiation therapy and patients with BP therapy due to an osteoporosis. In patients taking BPs due to a malignant disease, implant treatments are not recommended due to the high number of reported implant-related necrosis in this patient cohort. Outcomes of this review should, however, be regarded with caution due to the low level of evidence of the currently existing data. PMID: 30109302 [PubMed - in process]
Source: European Journal of Oral Implantology - Category: Dentistry Authors: Tags: Eur J Oral Implantol Source Type: research
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