Positive Effects of Bisphosphonates on Osteogenic Differentiation in Patient-Derived Mesenchymal Stem Cells for the Treatment of Osteoporosis

CONCLUSION:Our study using a clinically relevantin vitro model suggests that bisphosphonate treatment is more effective for patients with osteoporosis than its preventive effect for healthy person. In addition, patient-specific responses to bisphosphonates should be considered rather than bisphosphonate type prior to prescription. Further investigations are needed to determine how bisphosphonates influence hBMSCs function to mediate bone quality and turnover in osteoporotic patients. Such studies can generate novel approaches to treat age-related osteoporotic bone loss.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research

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Publication date: Available online 18 June 2018 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Natascia Di Iorgi, Katia Maruca, Giuseppa Patti, Stefano Mora Following the increased awareness about the central role of the pediatric age in building bone for life, clinicians face more than ever the necessity of assessing bone health in pediatric subjects at risk for early bone mass derangements or in healthy children, in order to optimize their bone mass accrual and prevent osteoporosis. Although the diagnosis of osteoporosis is not made solely upon bone mineral density measurements du...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 18 June 2018 Source:Journal of Food Composition and Analysis Author(s): Inmaculada Rodríguez, Arturo Hardisson, Soraya Paz, Carmen Rubio, Angel J. Gutiérrez, Juan R. Jaudenes, Antonio Burgos, Consuelo Revert Fluoride plays an important role in the prevention of dental decay and in the reduction of osteoporosis. However, due to the multiple dietary sources of fluoride, the recommended intake can be exceeded on a prolonged basis and may have a harmful effect on health. In particular, high intakes of fluoride can cause dental fluorosis in the child population. For the above re...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the preven...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Research article Source Type: research
This article presents an overview of the current, most common, and new and upcoming experimental approaches for the mechanical characterization of bone. The key outcome variables of mechanical testing, as well as interpretations of the results in the context of bone structure and biology are also discussed.Recent FindingsQuasi-static tests are the most commonly used for determining the resistance to structural failure by a single load at the organ (whole bone) level. The resistance to crack initiation or growth by fracture toughness testing and fatigue loading offers additional and more direct characterization of tissue ma...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewThe purpose of this review was to examine the recent changes in the surgical treatment of bone metastases and how the treatment paradigm has shifted with the improvement of adjuvant therapies. How surgery fits into the local and systemic treatment was reviewed for bone metastases in different areas.Recent FindingsThe more common use of targeted chemotherapies and focused high-dose radiation have altered the treatment paradigm of bone metastases.SummaryOverall changes in the surgical treatment of bone metastases have been driven by an increased multidisciplinary approach to metastatic cancer and the...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewTo summarize current evidence on the links between joint hypermobility (JH) and Ehlers-Danlos syndromes (EDS), with pain and reduced bone mass; to illustrate an updated approach to JH and EDS.Recent FindingsIn 2017, a novel classification for EDS and JH has been published. Increasing data demonstrate that pain is a major disability determinator in JH and EDS. Recent findings confirm a complex pathogenesis for pain in JH and EDS and suggest a potential role for joint instability, central sensitization and small fiber neuropathy. Some papers present bone mass reduction as an associated feature of JH ...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewConnecting organ-scale loads to cellular signals in their local in vivo environment is a current challenge in the field of bone (re)modelling. Understanding this critical missing link would greatly improve our ability to anticipate mechanotransduction during different modes of stimuli and the resultant cellular responses. This review characterises computational approaches that could enable coupling links across the multiple scales of bone.Recent FindingsCurrent approaches using strain and fluid shear stress concepts have begun to link organ-scale loads to cellular signals; however, these approaches...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate incorporation imparts important biomechanical and other functional properties to bone. However, which cells are responsible for citrate production in bone remains unclear and whether the citrate component changes with bone loss during osteoporosis is also not known. Here, we show that the citrate content is markedly reduced in the bone of mice or rats with age-related, ovariectomy-induced or retinoic acid-induced bone loss.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Hardy RS, Zhou H, Seibel MJ, Cooper MS Abstract Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. In addition, in recent years it has become clear that more subtle states of endogenous glucocorticoid excess may have a major impact on bone health. Adverse effects can be seen with mild systemic glucocorticoid excess but there is also evidence of tissue-specific regulation of glucocorticoid action within bone as a mechanism of disease. This review article will examine a) the role of endogenous glucocorticoids in normal bone physiology, b) the skeletal eff...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
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