Development of Tc99m DMSA Complex 2 Quality Control Test

Conclusion Using the 51A ITLC paper with 0.9% NaCl is an effective quality control method to identify and differentiate between Tc99m DMSA complex 1 and complex 2. The preferred Tc99m DMSA complex 2 remains mostly at origin with slow migration up the strip, whereas the Tc99m DMSA complex 1 migrates readily up the strip. Performing this quick and simple test on a preparation of Tc99m DMSA can help to ensure the correct complex is present for effective localization and imaging. This test may be more necessary when using compounded formulations of DMSA kits, as opposed to manufactured kits.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: TS27: Student Tech Papers III Source Type: research