Exploring the optimal reference to estimate the effect of anti-inflammatory therapy for the cardiac sarcoidosis -metabolic volume assessment of FDG PET-

1542Objectives: Cardiac sarcoidosis (CS) is rare but a potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and most notably sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays important roles not only in the diagnosis of CS but also in the evaluation of therapeutic effects of anti-inflammatory therapy. A volume-based analysis by FDG PET including cardiac metabolic volume (CMV) has emerged as a new assessment tool for measuring the volume within the boundary determined by reference tissue such as the liver and the blood pool uptake. However, oral steroid therapy could affect the uptake in the liver or in the blood pool uptake. Here, we attempted to evaluate and analyze the steroid effects on the liver and the blood pool uptake. Methods: A total of consecutive 38 patients who underwent FDG PET/CT for suspected or diagnosed CS were retrospectively enrolled. We assessed and compared the variation of liver and blood pool FDG uptake from pre- to during- steroid therapy. After the diagnosis of CS was established, oral steroid therapy was initiated. Daily maintenance dose of steroid was 27.6 ± 4.0 mg at the second scan and the duration between the scans was 61.5 ± 23.5 days. For the liver uptake, the threshold as SUVmean + 3 x standard deviation (SD) of the right lobe (RL) obtained from the semi-automated dedicated software and SUV assessed by manual process from th...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research

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The American Society of Nuclear Cardiology (ASNC) has published its 2018 guidelines...Read more on AuntMinnie.comRelated Reading: SNMMI, ASNC offer guidelines for myocardial perfusion imaging with PET Radiologist wins ASNC's 1st clinical abstract award Medical societies expand collaboration on cardiac registry ASNC, SNMMI advise on cardiac sarcoidosis ASNC releases guidance on MPI in women
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
We report a case of sarcoid-like granulomatous tumoral melanosis in a patient on the programmed cell death-1 (PD-1) receptor inhibitor pembrolizumab for metastatic melanoma. This is, to our knowledge, the first reported case of a sarcoidal form of tumoral melanosis in a patient on anti-PD-1 therapy. We postulate that this reflects tumor regression in response to pembrolizumab-induced immune activation, with concomitant therapy–triggered induction of a sarcoid-like reaction. These findings and the literature review presented herein should alert clinicians and pathologists to the possibility of regressed lesions with s...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Chronic hypersensitivity pneumonitis (CHP) is a common interstitial lung disease (ILD) frequently associated with lung fibrosis [1]. Among patients with CHP, the degree of pulmonary function impairment and the extent of fibrosis are known predictors of mortality [2, 3]. In other forms of ILD, such as idiopathic pulmonary fibrosis (IPF) and sarcoidosis, abnormal pulmonary haemodynamics measured during resting supine right heart catheterisation (RHC) are additionally associated with poor prognosis [4–7]. In CHP, however, the prognostic value of RHC is unknown.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Conclusion: Peptide receptor radionuclide therapy in sarcoidosis is feasible and might be a new valuable tool in patients with otherwise treatment-refractory disease. Given the long experience with and good tolerability of PRRT, further evaluation of this new treatment option for otherwise treatment-refractory sarcoidosis in larger patient cohorts is warranted.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conditions:   Sarcoidosis;   Cardiomyopathies Interventions:   Diagnostic Test: 18F-FDG-PET/MRI;   Diagnostic Test: 18F-GE180-PET/MRI Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology;   University Hospital, Essen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThis prospective study of neurosarcoidosis increases our understanding of the pathophysiology of the disease. A reclassification of the clinical and imaging features of the disease allows an understanding of its pathophysiology and correlation with CSF indices allows an early identification of those with a more destructive disease will help to define treatment and may thereby improve outcome.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractPurpose of ReviewThe goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.Recent FindingsWhile the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised distri...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
ConclusionThis case sheds the light on a complex regulation of PD-L1 expression in vivo on PBMC after nivolumab arrest and triggers the question of monitoring the expression of immune checkpoint on immune cells during and after treatment with ICI.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 155 Author(s): Bastien Joubert, Kevin Rostásy, Jérôme Honnorat Immune-mediated cerebellar ataxia (CA) comprises a group of rare diseases that are still incompletely described, and are probably underdiagnosed. Both acute and progressive progressions are possible. Different syndromes have been identified, including CA associated with anti-GAD antibodies, the cerebellar type of Hashimoto encephalopathy, primary autoimmune CA, gluten ataxia, opsoclonus-myoclonus syndrome, and paraneoplastic cerebellar degenerations. Most of these syndrome...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Chronic pulmonary aspergillosis (CPA) is a slowly progressive infection mainly caused by Aspergillus fumigatus, characterized by inflammatory destruction of lung tissue with cavitation, pleural thickening and/or fibrosis, and associated with significant respiratory and constitutional symptoms [1 –3]. CPA usually affects patients with underlying structural airway disease with air-filled cavities or bullae, such as tuberculosis (TB), non-tuberculous mycobacterial infection, chronic obstructive pulmonary disease (COPD), allergic bronchopulmonary aspergillosis (ABPA), pneumothorax and sarcoid osis.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
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