Exploring the optimal reference to estimate the effect of anti-inflammatory therapy for the cardiac sarcoidosis -metabolic volume assessment of FDG PET-

1542Objectives: Cardiac sarcoidosis (CS) is rare but a potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and most notably sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays important roles not only in the diagnosis of CS but also in the evaluation of therapeutic effects of anti-inflammatory therapy. A volume-based analysis by FDG PET including cardiac metabolic volume (CMV) has emerged as a new assessment tool for measuring the volume within the boundary determined by reference tissue such as the liver and the blood pool uptake. However, oral steroid therapy could affect the uptake in the liver or in the blood pool uptake. Here, we attempted to evaluate and analyze the steroid effects on the liver and the blood pool uptake. Methods: A total of consecutive 38 patients who underwent FDG PET/CT for suspected or diagnosed CS were retrospectively enrolled. We assessed and compared the variation of liver and blood pool FDG uptake from pre- to during- steroid therapy. After the diagnosis of CS was established, oral steroid therapy was initiated. Daily maintenance dose of steroid was 27.6 ± 4.0 mg at the second scan and the duration between the scans was 61.5 ± 23.5 days. For the liver uptake, the threshold as SUVmean + 3 x standard deviation (SD) of the right lobe (RL) obtained from the semi-automated dedicated software and SUV assessed by manual process from th...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research

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Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
AbstractPurpose of ReviewThe purpose of this review article is to present the spectrum of abnormalities and multi-modality imaging evaluations in patients with musculoskeletal sarcoidosis.Recent FindingsThe articular manifestations of sarcoidosis are difficult to distinguish from those of the other inflammatory and degenerative arthropathies, and the muscular lesions in sarcoidosis are generally clinically silent and therefore often missed. Magnetic resonance imaging has shown these manifestations to be very common in active sarcoidosis, and should thus be included in the screening if musculoskeletal sarcoidosis is suspect...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewThe purpose of this paper is to provide an updated review of recent advances in protocols for positron emission tomography (PET) or PET/computed tomography (PET/CT) imaging in patients with sarcoidosis.Recent FindingsThere has been more research focused on developing newer and improved PET imaging modalities to diagnose and follow-up cardiac sarcoidosis (CS). Fluorine-18-fluorodeoxyglucose (18F- FDG)-PET are widely used to diagnose CS, with or without concurrent rest nuclear myocardial perfusion study. There have been various patient preparation strategies for FDG PET/CT in CS. Interpretation crite...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
Authors: Vergnon JM, Tissot CL PMID: 30745234 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Much has been researched and written about the promise of PET/MRI. While the...Read more on AuntMinnie.comRelated Reading: Ga-68 PSMA-11 PET/MRI benefits prostate cancer patients TOF PET/MRI makes dose reduction viable for breast cancer How effective is PET/MRI for rectal cancer? PET/MRI with ferumoxytol MR contrast performs well for pediatric patients Cardiac FDG-PET/MRI's role in Anderson-Fabry disease
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A 64-year-old man from Iowa with a medical history of sarcoidosis, managed with prednisone, 20 mg/d, for the past 5 months, presented to the emergency department with gradual-onset, progressive altered mental status and headaches of 1 month ’s duration. Previously, he was cognitively intact according to his daughter. He had become unable to perform normal daily tasks such as unlocking doors and holding normal conversations. Additionally, he reported a generalized, throbbing, constant headache associated with intermittent blurry visio n.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents ’ clinic Source Type: research
n A Abstract Sarcoidosis is a T-cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)-macrophages, monocytes, and dendritic cells (DCs)-are likely critical in sarcoidosis as they initiate and maintain T cell activation and contribute to granuloma formation by cytokine production. Granulomas manifest primarily in lungs and lung-draining lymph nodes (LLNs) but these compartments are less studied compared to blood and bronchoalveolar lavage (BAL). Sarcoidosis can present with an acute onset (usually Löfgren's syndrome (LS)) or a gradual onset (non-LS). LS patients t...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research
PPARγ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model. Am J Respir Cell Mol Biol. 2019 Feb 11;: Authors: Malur A, Mohan A, Barrington RA, Leffler N, Malur A, Muller-Borer B, Murray G, Kew K, Zhou C, Russell J, Jones JL, Wingard CJ, Barna BP, Thomassen MJ Abstract We established a murine model of multiwall carbon nanotube (MWCNT)-elicited chronic granulomatous disease which bears similarities to human sarcoidosis pathology including alveolar macrophage deficiency of peroxisome-proliferator-activated receptor gamma (PPARγ). Because lymphocyte reac...
Source: American Journal of Respiratory Cell and Molecular Biology - Category: Molecular Biology Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
We present a delayed diagnosis of sarcoidosis in an 11-year-old girl by demonstrating ultrasonographic imaging findings of granulomatous cervical and abdominal lymph node involvement. Pulmonary interstitial fibrosis in addition to multi-compartmental enlarged echogenic lymph nodes could be considered sarcoidosis. Punctate echogenic foci in the cervical lymph nodes should be considered in the differential diagnosis of sarcoidosis.
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
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