Age and sex effects on synaptic density in healthy humans as assessed with SV2A PET

Conclusions: Using 11C‑UCB‑J, age-related synaptic density changes were found in caudate and thalamus; the functional significance of these reductions will require further study. BPND was 10% lower in females compared to males, but this result should be carefully interpreted given the lack of effects in VT. Further exploration of aging and sex effects on synaptic density will include 1) more detailed ROIs, 2) an increase in the older and female cohort, 3) partial volume correction, and 4) assessment of the impact of atlas ROIs on these analyses. References: 1. Nabulsi et al., JNMMI, 57:777-84, 2016. 2. Finnema et al., Sci Transl Med, 8:348:348ra96, 2016. 3. Finnema et al., JCBFM, epub, 2017. 4. Masilah et al., Neurology. 43:192-7, 1993.

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Carson, R., Naganawa, M., Matuskey, D., Mecca, A., Pittman, B., Toyonaga, T., Lu, Y., Dias, M., Nabulsi, N., Finnema, S., Chen, M.-K., Malison, R., Esterlis, I., van Dyck, C., Huang, Y. Tags: Probes for Neuroimaging I Source Type: research