Impacts of pre- and postnatal nutrition on glucagon regulation and hepatic signalling in sheep

In conclusion, prenatal undernutrition and postnatal overnutrition had similar long-term implications and reduced hepatic glucagon signalling. Glucagon secretory responses to propionate were, however, not related to the prenatal nutrition history, but negatively affected by the postnatal obesogenic diet. The pancreatic α-cell compared to β-cells may thus be less sensitive towards late gestation malnutrition, whereas hepatic glucagon signalling appears to be a target of prenatal programming.
Source: Journal of Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research