Impaired pupillary control in “schizophrenia-like” WISKET rats

Patients with schizophrenia show impairments in autonomic regulation, including pupillomotor control. The aim of this study was to explore the changes of pupillary light reflex in a new substrain (WISKET) with several schizophrenia-like alterations.Male WISKET rats housed individually (for four weeks) and treated with ketamine (for 3  × 5 days) after weaning and naive group-housed Wistar rats (controls) were involved in the study. The pupillary light reflex was studied in two series after sedation (diazepam) or anesthesia (chloral hydrate).
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Authors: Source Type: research