Rufinamide add-on therapy for refractory epilepsy.

CONCLUSIONS: In people with drug-resistant focal epilepsy, rufinamide when used as an add-on treatment was effective in reducing seizure frequency. However, the trials reviewed were of relatively short duration and provided no evidence for the long-term use of rufinamide. In the short term, rufinamide as an add-on was associated with several adverse events. This review focused on the use of rufinamide in drug-resistant focal epilepsy and the results cannot be generalised to add-on treatment for generalised epilepsies. Likewise, no inference can be made about the effects of rufinamide when used as monotherapy. PMID: 29691835 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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AbstractThis retrospective study explored the risk factors for the occurrence of seizures in the pre- and postoperative period in patients undergoing supratentorial meningiomas surgery to investigate those who are likely to benefit from prophylactic antiepileptic drugs (AEDs). We reviewed the medical records of 778 supratentorial meningiomas patients who were operated at our institution between 2011 and 2012. A total of 100 (12.9%) patients experienced preoperative seizures; 41 patients (5.3%) experienced postoperative in-hospital seizures, and 91 (13.5%,n = 673) patients experienced postoperative seizures af...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
The Green Clinics is the first board-certified medical cannabis clinic to open in the Kansas City area. The clinic has two doctors who are state licensed and board certified. They can evaluate patients and provide the necessary physician certification document if the patients meet state requirements. Qualifying conditions include cancer, epilepsy, intractable migraines, terminal illness and post-tra umatic stress disorder, among others. “Our clinic is not a rubber stamp,” CEO Emily Branch said…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
ConclusionsIn this retrospective study, the infliximab biosimilar was efficacious and safe for treating neurosarcoidosis.
Source: Journal of Neurology - Category: Neurology Source Type: research
Abstract PURPOSE OF REVIEW: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed. RECENT FINDINGS: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Additionally, as more data is being published on medi...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Opin Obstet Gynecol Source Type: research
According to this study, CBD causes hormonal changes that can lessen the intensity of anxiety disorders including generalized anxiety disorder, PTSD, and social anxiety. Regulates Behaviour &Cognition CBD interacts with a broad range of receptors, and through complicated processes, it works as a therapeutic agent. While behavioral patterns tend to be complicated for many people, there are ways that CBD can reduce destructive behavior and facilitate positive change. For instance, addiction is one of the areas that lead to unproductive behavioral patterns, and CBD has been used successfully to treat different forms of ad...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement brain cbd oil pickthebrain Source Type: blogs
A 26-year old warehouse employee first presented with subacute, holocephalic headache of moderate intensity, dizziness, and a "red, flickering pixel" in his right visual field, followed by two bilateral tonic-clonic seizures a few days later. The initial clinical examination, EEG, brain MRI and blood work were unremarkable except for rhabdomyolysis (CK ˜10.000 U/l; upper limit of normal is 190 U/l), which was considered as complication associated with tonic-clonic seizures. During the following months, the patient suffered from intermittend fluctuating right visual field phosphenes of increasing size and du...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Clinical letter Source Type: research
​BY JORDAN DEMCHUKA 59-year-old Caucasian man with a past medical history of well-controlled hypertension, hyperlipidemia, and gout presented to the ED with altered mental status. His wife reported that he was found two hours earlier in his home office confused, unable to recall plans made that morning, the current time and date, and his brother's death a year and a half earlier. She stated that the patient was repeating, “I don't know what's happening,” while anxiously pacing around the room. She said he had a history of falls and head injury at age 7, which was accompanied by brief amnesia that had not recu...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Introduction: In this recent study we have employed a novel type of stimulation, micro-magnetic stimulation ( μMS), for vagus nerve stimulation (VNS). Electrical VNS is commonly used to treat drug-resistant epilepsy, depression, and headache. However, oxidation/reduction reactions at the electrode-tissue interface can result in damage and reduce the efficacy of stimulation, while concerns regarding device and tissue damage prevent patients with VNS implants from receiving the diagnostic benefits of imaging devices such as magnetic resonance imaging (MRI).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Introduction: Electrical vagus nerve stimulation (VNS) is an FDA-approved treatment for drug-resistant epilepsy, depression, and headache. However, oxidation/reduction reactions at the electrode tissue interface can result in damage and reduce the efficacy of stimulation. Micro-magnetic stimulation ( μMS) of the vagus nerve has the potential to be an alternative to electrical VNS. μMS is accomplished by running alternating current through a sub-millimeter coil to produce time-varying magnetic fields which can in turn induce electrical fields, leading to neuronal activation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Conclusion: This study is one of the largest series about VPA-induced NE. NE is a side effect of VPA that is generally overlooked by clinicians and slightly less well-known too. The literature on VPA-induced NE is very inadequate, and its etiology is not clear. In our study, we did not detect renal dysfunction in the patients with VPA-induced NE; therefore, we may speculate that the NE was caused by the increased sleep depth with VPA treatment. We believe that larger prospective studies including polysomnography may be helpful to shed light on the cause of VPA-induced NE.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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