Rufinamide add-on therapy for refractory epilepsy.

CONCLUSIONS: In people with drug-resistant focal epilepsy, rufinamide when used as an add-on treatment was effective in reducing seizure frequency. However, the trials reviewed were of relatively short duration and provided no evidence for the long-term use of rufinamide. In the short term, rufinamide as an add-on was associated with several adverse events. This review focused on the use of rufinamide in drug-resistant focal epilepsy and the results cannot be generalised to add-on treatment for generalised epilepsies. Likewise, no inference can be made about the effects of rufinamide when used as monotherapy. PMID: 29691835 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

Related Links:

Valproate can be a very effective drug for treating epilepsy and bipolar disorder, but it can have serious detrimental effects on a foetus.Yet it remains widely-prescribed...
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Concerns about some flashy scenes in The Incredibles 2 movie hit social media, and Disney issued a warning for moviegoers with epilepsy.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
This study was conducted to evaluate the prevalence of headache subtypes, epilepsy, atopic disorders, motion sickness and recurrent abdominal pain among children and adolescents with ADHD and their parents.
Source: Brain and Development - Category: Neurology Authors: Tags: Original article Source Type: research
Stroke-like migraine attacks after radiation therapy (SMART) is a late-onset complication of cranial irradiation, clinically characterized by headache, seizures and focal deficits, with suggestive MRI changes. Clinical and neuroimaging findings typically resolve after a few weeks [1]. Seizures or status epilepticus are reported in 69% of SMART patients [2,3].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Short communication Source Type: research
Authors: Andrade C Abstract Valproate and formulations thereof are approved for the management of seizure disorders, bipolar disorder, and migraine. Valproate is also used for many off-label indications. Unfortunately, data from observational studies indicate that valproate is perhaps the most teratogenic drug in the neuropsychiatric pharmacopeia. It is significantly more teratogenic than many other antiepileptic drugs (AEDs). In observational studies, gestational exposure to valproate is also associated with higher risks of cognitive, language, and psychomotor delay during early childhood and possibly with an incr...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Neuro-feedback (NFB) is a therapy for treating various neurological diseases such as epilepsy, attention-deficit hyperactivity disorder, and migraine (Wyckoff and Strehl, 2011). The regulation of slow potentials (SPs) can be applied for alleviating the symptoms of brain disorders. The SPs recorded by the scalp electrodes area are generated in the cerebral cortex and are therefore called as slow cortical potentials (SCPs).
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Rationale: Purulent meningitis refers infection of the subarachnoid space by various purulent bacteria and the corresponding inflammation of the leptomeninges. However, purulent meningitis due to Rhodococcus equi is extremely rare. Patient concerns: A 40-year-old man presented with fever and intermittent headache for 6 days. Two hours prior to admission, he developed epileptic seizures. Diagnoses: Brain computed tomography and magnetic resonance imaging showed intracerebral malacic lesions. Bacterial culture of cerebrospinal fluid revealed the presence of R. equi. A diagnosis of purulent meningitis caused by R. equ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Authors: Campos AR, Biscoito L, Gasparinho MG Abstract Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. A 33-year-old male presented with a sudden headache and a generalized seizure. He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor ...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
[Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review]. Schmerz. 2018 May 23;: Authors: Martin P Abstract Besides postictal headaches, epileptic seizures are infrequently associated with pain experiences. Nevertheless, seizure-associated pain is an important clinical symptom to recognize, diagnose and to differentiate from non-epileptic disorders. Seizure-associated pain may shed light on the anatomical and pathophysiological foundation of pain in general. According to its localization seizure-related pain is classified as unilateral somatosensory, abdominal and cephalic ...
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research
TRENTON, N.J. (AP) — U.S. regulators Thursday approved the first drug designed to prevent chronic migraines. The Food and Drug Administration’s action clears the monthly shot Aimovig for sale. It’s the first in a new class of long-acting drugs for preventing migraines. Three other shots are expected to win approval by next year, and several pills for preventing migraines are being tested. Current prevention treatments include pills originally developed for epilepsy and other conditions, and the wrinkle reducer Botox, but many patients abandon them because they don’t provide enough relief or cause se...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Local TV Migraines talkers Source Type: news
More News: Brain | Child Development | Children | Clinical Trials | Databases & Libraries | Epilepsy | General Medicine | Headache | Inovelon | Migraine | Neurology | Rufinamide | Study