Mp81-15 prostate small cell carcinoma express stem cell factors that can transform normal and cancer cells into stem-like

Prostate cancer can be grouped into either luminal-like (differentiated) or stem-like (undifferentiated). The latter type includes small cell carcinoma. The LuCaP 145.1 small cell carcinoma xenograft line shows expression of stem cell transcription factors LIN28A, NANOG, POU5F1 and SOX2. Luminal-like adenocarcinoma LuCaP lines show expression of only one or two of these factors, while cancer cells of Gleason patterns 3 and 4 do not. Forced expression of these four genes in differentiated somatic cells produces induced pluripotent stem (iPS) cells.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Stem Cell Research: Stem Cell Research II Source Type: research